INT256900
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Sources of TEM were: 38.9% of the subjects made these concoctions themselves, 27.45% received TEM from relatives, 17.7% consulted a traditional healer, 13.27% received TEM from neighbors; and in 2.65% of subjects the source was unspecified. | |||||||||||||||
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There was no significant difference between the age of the patients and the source of TEM (P > 0.5). | |||||||||||||||
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This study has shown that many patients still use TEM for various ocular conditions including conjunctivitis, corneal ulcers, and trauma, which can cause blindness due to associated complications. | |||||||||||||||
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However, human AC cells showed expression of TNMD, which was absent from bovine AC samples. | |||||||||||||||
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Furthermore, there were also differences in cell-specific gene expression; notably, SNAP 25 and TNMD were expressed by human AC cells and FBLN 1 was expressed by human AF cells at levels very similar to those observed in AC cells. | |||||||||||||||
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Expression of a subset of the validated bovine markers genes (KRT8, 18, 19 SNAP25, CDH2, TNMD, BASP1, FOXF1, IBSP and FBLN 1) was analysed in human cells. | |||||||||||||||
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Sources of TEM were self-medication in 38.9% of subjects, relatives in 27.4%, and traditional healers in 17.7%.
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The symptoms necessitating the use of TEM, the type and source of TEM, history of trauma preceding use of TEM, complications, surgeries, presenting visual acuity, and final visual outcome were documented. | |||||||||||||||
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The symptoms necessitating the use of TEM, the type and source of TEM, history of trauma preceding use of TEM, complications, surgeries, presenting visual acuity, and final visual outcome were documented. | |||||||||||||||
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Sources of TEM were: 38.9% of the subjects made these concoctions themselves, 27.45% received TEM from relatives, 17.7% consulted a traditional healer, 13.27% received TEM from neighbors; and in 2.65% of subjects the source was unspecified. | |||||||||||||||
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The symptoms necessitating the use of TEM, the type and source of TEM, history of trauma preceding use of TEM, complications, surgeries, presenting visual acuity, and final visual outcome were documented. | |||||||||||||||
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Although the differential expression of TNMD seen in bovine samples between NP and AF cells was preserved in human samples (P < 0.05), the fold change was lower (approximately 100-fold in bovine, and approximately 5-fold in human). | |||||||||||||||
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Analysis of the IVD-specific marker genes (TNMD, BASP1, TNFAIP6, FOXF1 and FOXF2; Figure 3b) confirmed the microarray results, with expression being significantly higher in both NP and AF cells than AC cells (all genes P < 0.0001). | |||||||||||||||
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The additional genes, brain abundant, membrane attached signal protein 1 (BASP1), tenomodulin (TNMD), tumor necrosis factor, alpha-induced protein 6 (TNFAIP6), forkhead box F1 (FOXF1), forkhead box F2 (FOXF2) and aquaporin (AQP1) were included from the NP/AC comparisons (Table 6) because they had high differential expression levels but also had detectable levels of expression in the AF and were therefore of interest as transcriptional markers of an IVD cell. | |||||||||||||||
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The additional genes, brain abundant, membrane attached signal protein 1 (BASP1), tenomodulin (TNMD), tumor necrosis factor, alpha-induced protein 6 (TNFAIP6), forkhead box F1 (FOXF1), forkhead box F2 (FOXF2) and aquaporin (AQP1) were included from the NP/AC comparisons (Table 6) because they had high differential expression levels but also had detectable levels of expression in the AF and were therefore of interest as transcriptional markers of an IVD cell. | |||||||||||||||
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The additional genes, brain abundant, membrane attached signal protein 1 (BASP1), tenomodulin (TNMD), tumor necrosis factor, alpha-induced protein 6 (TNFAIP6), forkhead box F1 (FOXF1), forkhead box F2 (FOXF2) and aquaporin (AQP1) were included from the NP/AC comparisons (Table 6) because they had high differential expression levels but also had detectable levels of expression in the AF and were therefore of interest as transcriptional markers of an IVD cell. | |||||||||||||||
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The additional genes, brain abundant, membrane attached signal protein 1 (BASP1), tenomodulin (TNMD), tumor necrosis factor, alpha-induced protein 6 (TNFAIP6), forkhead box F1 (FOXF1), forkhead box F2 (FOXF2) and aquaporin (AQP1) were included from the NP/AC comparisons (Table 6) because they had high differential expression levels but also had detectable levels of expression in the AF and were therefore of interest as transcriptional markers of an IVD cell. | |||||||||||||||
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Eleven genes (SNAP25, KRT8, KRT18, KRT19, CDH2, IBSP, VCAN, TNMD, BASP1, FOXF1 & FBLN1) were also differentially expressed in normal human NP cells, although to a lesser degree. | |||||||||||||||
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Importantly, only one of these genes (TNMD) showed no expression in AC cells and given the large differences between its expression in NP and AF cells, TNMD may serve as a marker for the AF cell phenotype. | |||||||||||||||
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Presenting TE and in particular the ideal of transparency as natural undermines other ordinary experiences of our fleshy bodies: living a body also entails hurting, scarring oneself and paying heed to ones bodily existence. | |||||||||||||||
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