INT256975

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Context Info
Confidence 0.36
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 0
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Dlg1) endoplasmic reticulum (Dlg1) plasma membrane (Dlg1)
nucleus (Dlg1) cytoplasm (Dlg1)
Anatomy Link Frequency
lateral 1
basal cell 1
Dlg1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate receptor 20 60.64 Quite High
anesthesia 18 15.48 Low Low
ketamine 12 8.40 Low Low
Glutamate 31 5.00 Very Low Very Low Very Low
antagonist 9 5.00 Very Low Very Low Very Low
Spinal cord 7 5.00 Very Low Very Low Very Low
potassium channel 3 5.00 Very Low Very Low Very Low
Hippocampus 3 5.00 Very Low Very Low Very Low
conotoxin 1 5.00 Very Low Very Low Very Low
nMDA receptor 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 25 19.80 Low Low
Ganglion Cysts 18 5.00 Very Low Very Low Very Low
Injury 18 5.00 Very Low Very Low Very Low
Hypothermia 12 5.00 Very Low Very Low Very Low
Death 7 5.00 Very Low Very Low Very Low
Disease 7 5.00 Very Low Very Low Very Low
Proliferative Vitreoretinopathy 6 5.00 Very Low Very Low Very Low
Intellectual Impairment 3 5.00 Very Low Very Low Very Low
Rupture 2 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunoprecipitation studies confirmed an association among CD81, Sap97, and EBP50.
Sap97 Binding (association) of
1) Confidence 0.36 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2610370 Disease Relevance 0 Pain Relevance 0
To directly test for the binding of CD81 to Sap97 and EBP50, we did a series of immunoprecipitation studies.
Sap97 Binding (binding) of
2) Confidence 0.36 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2610370 Disease Relevance 0 Pain Relevance 0
Due to the distinct locations of these two PDZ proteins within the RPE, CD81 must be involved in at least two different molecular complexes, one in the microvilli associated with EBP50/Ezrin and the other associated with Sap97 on the lateral and basal cell surfaces.
Sap97 Binding (associated) of in basal cell
3) Confidence 0.28 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2610370 Disease Relevance 0 Pain Relevance 0
At P0 (Figure 4A-C, Figure 4M-O), there is little immunolabeling for Sap97 (Figure 4A), CD81 (Figure 4B,N), or EBP50 (Figure 4M).
Sap97 Binding (immunolabeling) of
4) Confidence 0.24 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2610370 Disease Relevance 0 Pain Relevance 0
This finding suggested not only that the C-terminal end of CD81 was a PDZ binding domain, but that the C-terminal end bound to a subset of PDZ proteins, Sap-97 and the Domina 1 of Mint and PTP.
Sap-97 Binding (bound) of
5) Confidence 0.23 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2610370 Disease Relevance 0 Pain Relevance 0
Due to the distinct locations of these two PDZ proteins within the RPE, CD81 must be involved in at least two different molecular complexes, one in the microvilli associated with EBP50/Ezrin and the other associated with Sap97 on the lateral and basal cell surfaces.
Sap97 Binding (associated) of in lateral
6) Confidence 0.09 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2610370 Disease Relevance 0 Pain Relevance 0
Based on drawing an analogy to the interaction between GluN2 and PSD-95, the interaction between GluA1 and SAP97 was identified by directly testing the interaction [90].
SAP97 Binding (interaction) of
7) Confidence 0.05 Published 2010 Journal Mol Neurobiol Section Body Doc Link PMC2992128 Disease Relevance 0 Pain Relevance 0.06

General Comments

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