INT256985

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Context Info
Confidence 0.39
First Reported 2007
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 0.20
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Dlg1) endoplasmic reticulum (Dlg1) plasma membrane (Dlg1)
nucleus (Dlg1) cytoplasm (Dlg1)
Anatomy Link Frequency
inner surface 2
Dlg1 (Rattus norvegicus)
Cd81 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 21 74.84 Quite High
ketamine 14 67.76 Quite High
Spinal cord 7 24.64 Low Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 21 80.36 Quite High
Hypothermia 14 61.00 Quite High
Injury 21 58.88 Quite High
Proliferative Vitreoretinopathy 7 45.52 Quite Low
Adhesions 28 5.00 Very Low Very Low Very Low
Death 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results demonstrate that CD81 is specifically associated with both Sap97 and EBP50.
Sap97 Binding (associated) of CD81
1) Confidence 0.39 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2610370 Disease Relevance 0 Pain Relevance 0
One could speculate that CD81 associated with Sap97 on the basolateral surface of cells has an important function in the final stages of RPE cell development and the stabilization of cellular contacts.
Sap97 Binding (associated) of CD81
2) Confidence 0.39 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2610370 Disease Relevance 0.06 Pain Relevance 0
To determine if the CD81 associated with Sap97 or EBP50, we used double-label immunohistochemistry similar to that described in Clarke and Geisert [3].
Sap97 Binding (associated) of CD81
3) Confidence 0.29 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2610370 Disease Relevance 0.06 Pain Relevance 0.17
To directly test for the binding of CD81 to Sap97 and EBP50, we did a series of immunoprecipitation studies.
Sap97 Binding (binding) of CD81
4) Confidence 0.29 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2610370 Disease Relevance 0 Pain Relevance 0
Sap97 labeling appeared in the developing RPE cell layer (Figure 6B) and was strongly associated with CD81 at the base of these cells (Figure 6C).
Sap97 Spec (appeared) Binding (associated) of CD81
5) Confidence 0.25 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2610370 Disease Relevance 0.08 Pain Relevance 0
In the RPE layer, synapse-associated protein 97 (Sap97) and CD81 were associated with the basolateral surface of the cells; ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) localizing with CD81 was found on microvilli at the inner surface of RPE cells.


synapse-associated protein 97 Binding (associated) of CD81 in inner surface
6) Confidence 0.25 Published 2007 Journal Molecular Vision Section Abstract Doc Link PMC2610370 Disease Relevance 0 Pain Relevance 0
In the RPE layer, synapse-associated protein 97 (Sap97) and CD81 were associated with the basolateral surface of the cells; ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) localizing with CD81 was found on microvilli at the inner surface of RPE cells.


Sap97 Binding (associated) of CD81 in inner surface
7) Confidence 0.25 Published 2007 Journal Molecular Vision Section Abstract Doc Link PMC2610370 Disease Relevance 0 Pain Relevance 0

General Comments

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