INT256987

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 0.06
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Slc9a3r1) nucleus (Slc9a3r1) cytoplasm (Slc9a3r1)
Anatomy Link Frequency
inner surface 2
Cd81 (Rattus norvegicus)
Slc9a3r1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 24 74.84 Quite High
ketamine 16 67.76 Quite High
Spinal cord 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypothermia 16 61.00 Quite High
Adhesions 32 5.00 Very Low Very Low Very Low
Injury 24 5.00 Very Low Very Low Very Low
Ganglion Cysts 24 5.00 Very Low Very Low Very Low
Proliferative Vitreoretinopathy 8 5.00 Very Low Very Low Very Low
Death 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the apical surface of the cells, CD81 is associated with EBP50, and these proteins are upregulated on a similar time course as the RPE matures.
CD81 Binding (associated) of EBP50
1) Confidence 0.43 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2610370 Disease Relevance 0 Pain Relevance 0
However, we do know that CD81 is associated with EBP50 on the inner RPE microvilli.
CD81 Binding (associated) of EBP50
2) Confidence 0.43 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2610370 Disease Relevance 0 Pain Relevance 0
These results demonstrate that CD81 is specifically associated with both Sap97 and EBP50.
CD81 Binding (associated) of EBP50
3) Confidence 0.43 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2610370 Disease Relevance 0 Pain Relevance 0
To determine if the CD81 associated with Sap97 or EBP50, we used double-label immunohistochemistry similar to that described in Clarke and Geisert [3].
CD81 Binding (associated) of EBP50
4) Confidence 0.32 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2610370 Disease Relevance 0.06 Pain Relevance 0.17
In the RPE layer, synapse-associated protein 97 (Sap97) and CD81 were associated with the basolateral surface of the cells; ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) localizing with CD81 was found on microvilli at the inner surface of RPE cells.


CD81 Binding (associated) of ezrin-radixin-moesin-binding phosphoprotein 50 in inner surface
5) Confidence 0.32 Published 2007 Journal Molecular Vision Section Abstract Doc Link PMC2610370 Disease Relevance 0 Pain Relevance 0
In the RPE layer, synapse-associated protein 97 (Sap97) and CD81 were associated with the basolateral surface of the cells; ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) localizing with CD81 was found on microvilli at the inner surface of RPE cells.


CD81 Binding (associated) of EBP50 in inner surface
6) Confidence 0.32 Published 2007 Journal Molecular Vision Section Abstract Doc Link PMC2610370 Disease Relevance 0 Pain Relevance 0
The C-terminal intracellular sequences of CD81 bound to three putative PDZ domains that potentially represented domains on Sap97 and EBP50.
CD81 Binding (bound) of EBP50
7) Confidence 0.32 Published 2007 Journal Molecular Vision Section Abstract Doc Link PMC2610370 Disease Relevance 0 Pain Relevance 0
To directly test for the binding of CD81 to Sap97 and EBP50, we did a series of immunoprecipitation studies.
CD81 Binding (binding) of EBP50
8) Confidence 0.32 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2610370 Disease Relevance 0 Pain Relevance 0

General Comments

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