INT2570

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Context Info
Confidence 0.43
First Reported 1979
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 2.88
Pain Relevance 2.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (Ache) extracellular space (Ache) extracellular region (Ache)
cell adhesion (Ache) Golgi apparatus (Ache) plasma membrane (Ache)
Anatomy Link Frequency
cortex 4
brain 3
cerebellum 3
medulla 1
cerebrospinal fluid 1
Ache (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Serotonin 4 100.00 Very High Very High Very High
medulla 4 100.00 Very High Very High Very High
tetrodotoxin 13 99.98 Very High Very High Very High
Hippocampus 12 99.08 Very High Very High Very High
Thalamus 8 98.56 Very High Very High Very High
fluoxetine 3 76.40 Quite High
anesthesia 7 75.00 Quite High
cerebral cortex 16 70.44 Quite High
Migraine 1 67.16 Quite High
antagonist 2 62.36 Quite High
Disease Link Frequency Relevance Heat
Disease 39 94.20 High High
Aging 29 91.52 High High
Disorder Of Lipid Metabolism 7 90.84 High High
Sprains And Strains 3 85.76 High High
Neurodegenerative Disease 3 83.72 Quite High
Urological Neuroanatomy 18 81.20 Quite High
Cirrhosis 41 80.64 Quite High
Shock 18 74.72 Quite High
Dementia 6 71.32 Quite High
Lewy Body Disease 1 70.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Acetylcholinesterase expressed in terms of wet weight was found to increase in the cerebellum, medulla, and to decrease in the medial cortex, hippocampus, thalamus and caudate nucleus.
Negative_regulation (decrease) of in medulla Gene_expression (expressed) of Acetylcholinesterase in cerebellum associated with medulla, thalamus and hippocampus
1) Confidence 0.43 Published 1979 Journal Zh. Evol. Biokhim. Fiziol. Section Abstract Doc Link 473984 Disease Relevance 0.23 Pain Relevance 0.29
Intraocular injections of tetrodotoxin reduce transiently expressed acetylcholinesterase activity in developing rat visual cortex.
Negative_regulation (reduce) of Gene_expression (expressed) of acetylcholinesterase in cortex associated with tetrodotoxin
2) Confidence 0.43 Published 1989 Journal Brain Res. Dev. Brain Res. Section Title Doc Link 2706772 Disease Relevance 0 Pain Relevance 0.37
One hour after righting reflex recovery, the escape latencies of all the rats were recorded again, and the level of AChE expression in the forebrain cortex was measured quantitatively.
Negative_regulation (measured) of Gene_expression (expression) of AChE in cortex
3) Confidence 0.43 Published 2008 Journal Nan Fang Yi Ke Da Xue Xue Bao Section Body Doc Link 18250048 Disease Relevance 0.06 Pain Relevance 0
Because TTX did not prevent the increase in AChE expression, it appears that the effects of mechanical stimulation are independent of electrical activity, which further indicates the use of an alternate signaling pathway.
Negative_regulation (prevent) of Gene_expression (expression) of AChE associated with tetrodotoxin
4) Confidence 0.42 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9435507 Disease Relevance 0.07 Pain Relevance 0.26
Tetrodotoxin (TTX) treatment did not prevent the increase in AChE expression, whereas nifedipine partially blocked it.
Negative_regulation (prevent) of Gene_expression (expression) of AChE associated with tetrodotoxin
5) Confidence 0.42 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9435507 Disease Relevance 0.09 Pain Relevance 0.27
A dual inhibitor of acetylcholinesterase (AChE) and serotonin transporter (SERT), RS-1259 (4-[1S)-methylamino-3-(4-nitrophenoxy)]propylphenyl N,N-dimethylcarbamate (fumaric acid)(1/2)salt), was newly synthesized.
Negative_regulation (inhibitor) of Gene_expression (synthesized) of acetylcholinesterase associated with serotonin
6) Confidence 0.41 Published 2003 Journal J. Pharmacol. Sci. Section Abstract Doc Link 14501158 Disease Relevance 0.07 Pain Relevance 0.21
A dual inhibitor of acetylcholinesterase (AChE) and serotonin transporter (SERT), RS-1259 (4-[1S)-methylamino-3-(4-nitrophenoxy)]propylphenyl N,N-dimethylcarbamate (fumaric acid)(1/2)salt), was newly synthesized.
Negative_regulation (inhibitor) of Gene_expression (synthesized) of AChE associated with serotonin
7) Confidence 0.41 Published 2003 Journal J. Pharmacol. Sci. Section Abstract Doc Link 14501158 Disease Relevance 0.07 Pain Relevance 0.21
Estimation of AChE activity in the brain
Negative_regulation (Estimation) of Gene_expression (activity) of AChE in brain
8) Confidence 0.41 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2937319 Disease Relevance 0.28 Pain Relevance 0.06
Thus, the possibility that overall decreases in peripheral AChE activity in BDL rats may influence cerebrospinal fluid contents and trigger a central response, resulting in the accumulation of AChE in the brain, also deserves consideration.
Negative_regulation (decreases) of in cerebrospinal fluid Gene_expression (rats) of AChE in brain
9) Confidence 0.36 Published 2008 Journal Brain Section Body Doc Link PMC2577805 Disease Relevance 0.31 Pain Relevance 0
Detection of AChE subunits by western blotting
Negative_regulation (Detection) of Gene_expression (Detection) of AChE
10) Confidence 0.36 Published 2008 Journal Brain Section Body Doc Link PMC2577805 Disease Relevance 0 Pain Relevance 0.07
Acetylcholinesterase expressed in terms of wet weight was found to increase in the cerebellum, medulla, and to decrease in the medial cortex, hippocampus, thalamus and caudate nucleus.
Negative_regulation (decrease) of Gene_expression (expressed) of Acetylcholinesterase in cerebellum associated with medulla, thalamus and hippocampus
11) Confidence 0.15 Published 1979 Journal Zh. Evol. Biokhim. Fiziol. Section Abstract Doc Link 473984 Disease Relevance 0.23 Pain Relevance 0.29
Some of these changes may tend to counterbalance one another; that is, decreased acetylcholinesterase levels may be offset by decreased levels of acetylcholine synthesis or acetylcholine receptors (Overstreet 2000).
Negative_regulation (decreased) of Gene_expression (levels) of acetylcholinesterase
12) Confidence 0.11 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1280410 Disease Relevance 0.38 Pain Relevance 0.06
[Scope and limitations of acetylcholinesterase inhibitors].
Negative_regulation (limitations) of Gene_expression ([Scope) of acetylcholinesterase
13) Confidence 0.03 Published 2004 Journal Nippon Yakurigaku Zasshi Section Title Doc Link 15333989 Disease Relevance 1.08 Pain Relevance 0.10

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