INT25706

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Context Info
Confidence 0.54
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 2.30
Pain Relevance 2.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neuronal 1
NA (Homo sapiens)
Pain Link Frequency Relevance Heat
adenocard 7 100.00 Very High Very High Very High
Potency 1 98.58 Very High Very High Very High
sodium channel 9 98.48 Very High Very High Very High
Dynorphin 7 97.28 Very High Very High Very High
Hyperalgesia 25 96.68 Very High Very High Very High
withdrawal 1 96.12 Very High Very High Very High
cocaine 1 95.68 Very High Very High Very High
imagery 12 93.68 High High
fibrosis 7 93.52 High High
Inflammatory mediators 112 92.96 High High
Disease Link Frequency Relevance Heat
Hyperalgesia 25 96.68 Very High Very High Very High
Cystic Fibrosis 7 93.52 High High
INFLAMMATION 188 92.56 High High
Nociception 24 86.84 High High
Disease 9 86.32 High High
Cancer 6 82.64 Quite High
Necrosis 5 82.16 Quite High
Ganglion Cysts 4 75.00 Quite High
Neuropathic Pain 10 25.00 Low Low
Heart Rate Under Development 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here we review the available evidence for the regulation of Na+ channels by phosphorylation, its molecular mechanism, and the possible ways in which it affects neuronal function.
Phosphorylation (phosphorylation) of Na in neuronal
1) Confidence 0.54 Published 2001 Journal Nat. Rev. Neurosci. Section Abstract Doc Link 11389473 Disease Relevance 0.10 Pain Relevance 0.23
Veratrine inhibited the partial reactions such as Na+-dependent phosphorylation and K+-stimulated phosphatase as well as the specific binding of [3H]ouabain.
Phosphorylation (phosphorylation) of Na
2) Confidence 0.07 Published 1989 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2537413 Disease Relevance 0 Pain Relevance 0.20
Na/K ATPase Sodium potassium adenosine triphosphatase
Phosphorylation (triphosphatase) of Na associated with adenocard
3) Confidence 0.07 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.84 Pain Relevance 0.36
A set of increasing concentrations for pyrithione-Na (KV7.1 opener at 5 ?
Phosphorylation (opener) of Na
4) Confidence 0.05 Published 2010 Journal Respir Res Section Body Doc Link PMC2889873 Disease Relevance 0 Pain Relevance 0
Dynorphin-A(1-13) inhibited the partial reactions of Na+, K+-ATPase at the different degree of the potency; the inhibition of K+-stimulated phosphatase was greater than that of Na+-dependent phosphorylation.
Phosphorylation (phosphorylation) of Na associated with dynorphin and potency
5) Confidence 0.04 Published 1988 Journal Life Sci. Section Abstract Doc Link 2893234 Disease Relevance 0 Pain Relevance 0.80
Immunohistochemical experiments revealed that phosphorylation of the Na+-K+-2Cl- cotransporter NKCC1 coincides with this increase of Cl- levels.
Phosphorylation (phosphorylation) of Na
6) Confidence 0.01 Published 2008 Journal Mol Pain Section Body Doc Link PMC2526990 Disease Relevance 0.77 Pain Relevance 0.59
This effect coincided with enhanced phosphorylation of the Na+-K+-2Cl- cotransporter NKCC1, suggesting that an increased activity of that transporter caused the early rise of intracellular Cl- levels.
Phosphorylation (phosphorylation) of Na
7) Confidence 0.01 Published 2008 Journal Mol Pain Section Abstract Doc Link PMC2526990 Disease Relevance 0.59 Pain Relevance 0.36

General Comments

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