INT25709

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Context Info
Confidence 0.56
First Reported 1989
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 9.38
Pain Relevance 3.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Igf2) extracellular space (Igf2) extracellular region (Igf2)
carbohydrate metabolic process (Igf2)
Anatomy Link Frequency
MSA 2
liver 1
spinal cord 1
brain 1
blood 1
Igf2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tetrodotoxin 7 99.96 Very High Very High Very High
fluoxetine 10 99.84 Very High Very High Very High
long-term potentiation 5 99.80 Very High Very High Very High
agonist 2 98.56 Very High Very High Very High
antagonist 4 97.52 Very High Very High Very High
Sciatic nerve 3 97.20 Very High Very High Very High
Spinal cord 6 96.56 Very High Very High Very High
Hippocampus 8 91.00 High High
imagery 1 90.00 High High
Serotonin 2 88.72 High High
Disease Link Frequency Relevance Heat
Multiple System Atrophy 25 100.00 Very High Very High Very High
Chronic Hepatitis 1 99.84 Very High Very High Very High
Neuropathic Pain 3 98.72 Very High Very High Very High
Liver Disease 3 98.56 Very High Very High Very High
Cancer 3 98.24 Very High Very High Very High
Cirrhosis 1 98.00 Very High Very High Very High
Hepatocellular Cancer 3 96.52 Very High Very High Very High
Obesity 9 96.08 Very High Very High Very High
Diabetes Mellitus 25 95.84 Very High Very High Very High
Body Weight 4 88.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There was a significant early reduction in IGF-II mRNA content as measured per mg of wet tissue or per poly(A)+ RNA in sciatic nerves, spinal cord and brain from spontaneously diabetic obese (fa/fa) vs. nondiabetic lean (+/+) adult rats.
Negative_regulation (reduction) of IGF-II in sciatic nerves associated with diabetes mellitus, obesity, sciatic nerve and spinal cord
1) Confidence 0.56 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9336345 Disease Relevance 1.47 Pain Relevance 0.39
After removal of the tumor, the blood sugar level gradually normalized (90-100 mg/dl) and the plasma insulin-like growth factor-II (IGF-II) level promptly decreased.
Negative_regulation (decreased) of IGF-II in blood associated with cancer
2) Confidence 0.54 Published 1998 Journal Jpn. J. Clin. Oncol. Section Abstract Doc Link 9657015 Disease Relevance 1.07 Pain Relevance 0.13
However, FLX administration increased IGF-II concentrations in the ventromedial hypothalamus and decreased IGF-II content in the lateral hypothalamus compared to vehicle injected.
Negative_regulation (decreased) of IGF-II in lateral associated with fluoxetine
3) Confidence 0.43 Published 1993 Journal Regul. Pept. Section Abstract Doc Link 8265809 Disease Relevance 0.55 Pain Relevance 0.51
Anterior pituitary levels of IGF-II were also decreased by FLX.
Negative_regulation (decreased) of IGF-II in Anterior pituitary associated with fluoxetine
4) Confidence 0.43 Published 1993 Journal Regul. Pept. Section Abstract Doc Link 8265809 Disease Relevance 0.52 Pain Relevance 0.51
In order to ascertain whether the EC and FF are still involved in PAR memorization during consolidation, the coupled fully reversible functional tetrodotoxin (TTX) inactivation of MSA, FF and EC was performed in rats having undergone a PAR training.
Negative_regulation (inactivation) of MSA in MSA associated with tetrodotoxin and multiple system atrophy
5) Confidence 0.38 Published 1999 Journal Brain Res. Section Abstract Doc Link 10064837 Disease Relevance 0.41 Pain Relevance 0.36
We assessed the effects of reversible inactivation of the medial septal area (MSA) on long-term potentiation (LTP) and recurrent inhibition in the dentate gyrus of urethane-anesthetized rats, in vivo.
Negative_regulation (inactivation) of MSA in medial associated with long-term potentiation and multiple system atrophy
6) Confidence 0.37 Published 1996 Journal Brain Res. Section Abstract Doc Link 8896806 Disease Relevance 0.25 Pain Relevance 0.30
Serum IGF-II levels (mean +/- SE) were decreased in chronic hepatitis (538 +/- 51 ng/ml; N = 29), liver cirrhosis (427 +/- 45; 50) and PHC (260 +/- 41; 17) compared to controls (830 +/- 49; 57).
Negative_regulation (decreased) of Serum IGF-II in liver associated with chronic hepatitis, cirrhosis and hepatocellular cancer
7) Confidence 0.32 Published 1989 Journal Dig. Dis. Sci. Section Abstract Doc Link 2537715 Disease Relevance 1.31 Pain Relevance 0.15
There was a significant early reduction in IGF-II mRNA content as measured per mg of wet tissue or per poly(A)+ RNA in sciatic nerves, spinal cord and brain from spontaneously diabetic obese (fa/fa) vs. nondiabetic lean (+/+) adult rats.
Negative_regulation (reduction) of IGF-II in brain associated with diabetes mellitus, obesity, sciatic nerve and spinal cord
8) Confidence 0.19 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9336345 Disease Relevance 1.47 Pain Relevance 0.39
There was a significant early reduction in IGF-II mRNA content as measured per mg of wet tissue or per poly(A)+ RNA in sciatic nerves, spinal cord and brain from spontaneously diabetic obese (fa/fa) vs. nondiabetic lean (+/+) adult rats.
Negative_regulation (reduction) of IGF-II in spinal cord associated with diabetes mellitus, obesity, sciatic nerve and spinal cord
9) Confidence 0.19 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9336345 Disease Relevance 1.47 Pain Relevance 0.39
The blockade of MSA-DB H2 receptors, caused by local perfusion with the H2 receptor antagonist cimetidine, moderated the spontaneous release of hippocampal ACh and antagonized the facilitation produced by H3 receptor antagonists.
Negative_regulation (blockade) of MSA-DB associated with antagonist and multiple system atrophy
10) Confidence 0.14 Published 2002 Journal Eur. J. Neurosci. Section Abstract Doc Link 12059975 Disease Relevance 0.65 Pain Relevance 0.57
In order to ascertain the rat perirhinal cortex (PC) function during early consolidation of a passive avoidance response (PAR), and to ascertain whether there are some functional interactions with the medial septal area (MSA), the fimbria-fornix complex (FF) and the entorhinal cortex (EC), PC-MSA, PC-FF, and PC-EC coupled inactivations were performed immediately after the PAR acquisition session.
Negative_regulation (inactivations) of PC-MSA in MSA associated with multiple system atrophy
11) Confidence 0.09 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10686385 Disease Relevance 0.20 Pain Relevance 0.07

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