INT25710

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Context Info
Confidence 0.62
First Reported 1989
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 3.10
Pain Relevance 1.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Igf2) extracellular space (Igf2) extracellular region (Igf2)
carbohydrate metabolic process (Igf2)
Anatomy Link Frequency
pituitary 2
uterus 1
bowel 1
nociceptors 1
posterior pituitary 1
Igf2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fluoxetine 15 98.48 Very High Very High Very High
Chronic pancreatitis 1 95.88 Very High Very High Very High
spastic colon 1 93.00 High High
Central nervous system 4 80.20 Quite High
Serotonin 3 69.12 Quite High
Bile 1 63.28 Quite High
Pain 4 50.00 Quite Low
cytokine 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Neuropathic pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 6 99.12 Very High Very High Very High
Diabetes Mellitus 1 98.44 Very High Very High Very High
Hepatocellular Cancer 3 97.72 Very High Very High Very High
Body Weight 6 97.58 Very High Very High Very High
Pancreatic Cancer 1 97.36 Very High Very High Very High
Appetite Loss 9 97.26 Very High Very High Very High
Cirrhosis 2 96.72 Very High Very High Very High
Pancreatitis 1 95.88 Very High Very High Very High
Chronic Hepatitis 1 94.96 High High
Ulcers 1 94.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While ABA and body weight loss altered peripheral IGF-II concentrations compared to ad libitum fed or exercised controls, these treatments had no effect on hypothalamic or posterior pituitary IGF-II content.
Neg (no) Regulation (effect) of IGF-II in posterior pituitary associated with appetite loss and body weight
1) Confidence 0.62 Published 1993 Journal Regul. Pept. Section Abstract Doc Link 8265809 Disease Relevance 0.60 Pain Relevance 0.51
Hypothalamic and pituitary insulin-like growth factor II (IGF-II) peptide concentrations are differentially regulated by factors associated with metabolism such as insulin and glucoprivation.
Regulation (regulated) of insulin-like growth factor II in pituitary
2) Confidence 0.54 Published 1993 Journal Regul. Pept. Section Abstract Doc Link 8265809 Disease Relevance 0.37 Pain Relevance 0.22
Serum IGF-II was not different from controls in any of nonhepatic diseases such as diabetes (1032 +/- 97; 19) pancreatic cancer (1413 +/- 282; 8), chronic pancreatitis (999 +/- 126; 17), peptic ulcer (1186 +/- 43; 11), irritable bowel syndrome (1002 +/- 109; 12), gastrointestinal tract cancer (1250 +/- 216; 21) and chronic renal failure (733 +/- 135; 14).
Neg (not) Regulation (controls) of Serum IGF-II in bowel associated with chronic renal failure, diabetes mellitus, spastic colon, ulcers, pancreatic cancer, gastrointestinal neoplasms, disease and chronic pancreatitis
3) Confidence 0.38 Published 1989 Journal Dig. Dis. Sci. Section Abstract Doc Link 2537715 Disease Relevance 1.46 Pain Relevance 0.22
CONCLUSIONS/SIGNIFICANCE: Low pH leads to changes in several electrical properties of MSA, including initiation of ectopic action potentials which could propagate centrally but could also invade the peripheral endings causing glutamate release and activation of nearby nociceptors within the spindle capsule.
Regulation (changes) of MSA in nociceptors
4) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link 20559566 Disease Relevance 0 Pain Relevance 0
Hypothalamic and pituitary insulin-like growth factor II (IGF-II) peptide concentrations are differentially regulated by factors associated with metabolism such as insulin and glucoprivation.
Regulation (regulated) of IGF-II in pituitary
5) Confidence 0.27 Published 1993 Journal Regul. Pept. Section Abstract Doc Link 8265809 Disease Relevance 0.37 Pain Relevance 0.22
Insulin-like growth factor II (IGF2) was regulated in the estrogen-treated rat uterus (Table 3), but had previously been reported to be estrogen non-responsive.
Regulation (regulated) of Insulin-like growth factor II in uterus
6) Confidence 0.10 Published 2007 Journal BMC Womens Health Section Body Doc Link PMC1852551 Disease Relevance 0.30 Pain Relevance 0

General Comments

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