INT257197

Context Info Confidence 0.03 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.08

lyase activity (Npr1) plasma membrane (Npr1) intracellular (Npr1)

Anatomy Link Frequency smooth muscle cells 1 Npr1 (Mus musculus)

Pain Link Frequency Relevance Heat Central nervous system 15 79.84 agonist 6 71.68 Cannabinoid 3 13.72 nMDA receptor 27 5.00 GABAergic 15 5.00 long-term potentiation 13 5.00 Serotonin 11 5.00 depression 11 5.00 Endocannabinoid 11 5.00 Neurotransmitter 11 5.00

Disease Link Frequency Relevance Heat Depression 11 5.00 Increased Venous Pressure Under Development 4 5.00 Injury 3 5.00 Targeted Disruption 3 5.00 Ganglion Cysts 3 5.00 Neurodegenerative Disease 2 5.00 Shock 2 5.00 Stress 2 5.00 Cv Unclassified Under Development 2 5.00 Demyelinating Disease 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Recent evidence indicates that phosphorylation by cAMP-dependent protein kinase enhances the associated guanylyl cyclase activity at resting levels of NO in pituitary cells (Kostic et al., 2004) whereas, in gastrointestinal smooth muscle cells, activation of muscarinic M2 receptors reduces cGMP generation through Src kinase-dependent tyrosine phosphorylation of the receptor (Murthy, 2008).

Phosphorylation (phosphorylation) of cyclase in smooth muscle cells

1) Confidence 0.03 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2610389 Disease Relevance 0 Pain Relevance 0.08

General Comments

This test has worked.