INT257199

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Context Info
Confidence 0.45
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 8
Disease Relevance 0.68
Pain Relevance 5.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nos1) mitochondrion (Nos1) oxidoreductase activity (Nos1)
plasma membrane (Nos1) cytoskeleton (Nos1) nucleus (Nos1)
Nos1 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 588 99.52 Very High Very High Very High
Kinase C 276 98.24 Very High Very High Very High
Morphine 539 97.96 Very High Very High Very High
tolerance 196 93.88 High High
Analgesic 133 93.48 High High
nMDA receptor 34 86.76 High High
Calcium channel 7 86.52 High High
Glutamate 77 83.16 Quite High
Periaqueductal grey 126 72.52 Quite High
antagonist 56 71.92 Quite High
Disease Link Frequency Relevance Heat
Neuroblastoma 1 100.00 Very High Very High Very High
Urological Neuroanatomy 127 72.52 Quite High
Apoptosis 7 69.84 Quite High
Death 7 58.32 Quite High
Nociception 49 5.00 Very Low Very Low Very Low
Pain 22 5.00 Very Low Very Low Very Low
Sprains And Strains 21 5.00 Very Low Very Low Very Low
Intractable Pain 14 5.00 Very Low Very Low Very Low
Depression 11 5.00 Very Low Very Low Very Low
Injury 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Considering that time 0 is the moment of morphine icv-injection, the earliest event observed was Akt activation, which was immediately followed by the activating phosphorylation of nNOS.
Positive_regulation (activating) of Phosphorylation (phosphorylation) of nNOS associated with morphine
1) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0 Pain Relevance 1.09
The rapid and transient MOR-dependent Akt-mediated nNOS serine1417 phosphorylation followed by sustained CaMKII phosphorylation of serine847 has also been observed for NMDAR-activated PI3K-Akt [38].
Positive_regulation (followed) of Phosphorylation (phosphorylation) of nNOS associated with opioid receptor
2) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0 Pain Relevance 0.50
Akt induces a rapid and transient phosphorylation of nNOS Ser1417 (7) resulting in increased NO production (8), release of zinc ions from metallothioneins (9) and recruitment of PKC?
Positive_regulation (resulting) of Phosphorylation (phosphorylation) of nNOS Ser1417 associated with kinase c
3) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0 Pain Relevance 0.30
Moreover, transient Akt-activating phosphorylation of nNOS Ser1417 [38] was followed by a robust increase in CaMKII-mediated inactivating phosphorylation of nNOS Ser847 [57].
Positive_regulation (activating) of Phosphorylation (phosphorylation) of nNOS Ser1417
4) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0.19 Pain Relevance 1.04
The rapid and transient MOR-dependent Akt-mediated nNOS serine1417 phosphorylation followed by sustained CaMKII phosphorylation of serine847 has also been observed for NMDAR-activated PI3K-Akt [38].
Positive_regulation (observed) of Phosphorylation (phosphorylation) of nNOS associated with opioid receptor
5) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0 Pain Relevance 0.55
Moreover, transient Akt-activating phosphorylation of nNOS Ser1417 [38] was followed by a robust increase in CaMKII-mediated inactivating phosphorylation of nNOS Ser847 [57].
Positive_regulation (increase) of Phosphorylation (phosphorylation) of nNOS
6) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0.20 Pain Relevance 1.08
Moreover, transient Akt-activating phosphorylation of nNOS Ser1417 [38] was followed by a robust increase in CaMKII-mediated inactivating phosphorylation of nNOS Ser847 [57].
Positive_regulation (mediated) of Phosphorylation (phosphorylation) of nNOS
7) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0.20 Pain Relevance 1.08
Phosphorylation of nNOS in neuroblastoma cells incubated with a phosphatase inhibitor occurred on threonine-1296 resulting in an ?
Positive_regulation (resulting) of Phosphorylation (Phosphorylation) of nNOS associated with neuroblastoma
8) Confidence 0.17 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2610389 Disease Relevance 0.10 Pain Relevance 0.15

General Comments

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