INT257200

Context Info Confidence 0.25 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 0 Pain Relevance 0.94

cytosol (Pde5a) signal transduction (Pde5a)

Anatomy Link Frequency intermediary 1 spike 1 Pde5a (Mus musculus)

Pain Link Frequency Relevance Heat Action potential 27 98.50 gABA 21 97.24 Neurotransmitter 33 96.96 medulla 6 88.08 tetrodotoxin 9 68.32 GABAergic 45 66.40 nMDA receptor 81 5.00 Central nervous system 45 5.00 long-term potentiation 39 5.00 Serotonin 33 5.00

Disease Link Frequency Relevance Heat Ganglion Cysts 9 10.36 Depression 33 5.00 Increased Venous Pressure Under Development 12 5.00 Injury 9 5.00 Targeted Disruption 9 5.00 Neurodegenerative Disease 6 5.00 Shock 6 5.00 Stress 6 5.00 Cv Unclassified Under Development 6 5.00 Demyelinating Disease 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Interestingly, Kv3 channels, which affect transmitter release by shaping the presynaptic action potential, have been found, when expressed in CHO cells, to be suppressed by the NO–cGMP pathway, not through direct phosphorylation by PKG but through the intermediary of a phosphatase, which probably removes a phosphate group from the channel protein that normally promotes activity (Moreno et al., 2001).

Phosphorylation (phosphorylation) of cGMP in intermediary associated with action potential

1) Confidence 0.25 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2610389 Disease Relevance 0 Pain Relevance 0.36

Specifically, stimulation of Ca2+-activated K+ channels by cGMP-dependent phosphorylation enhanced presynaptic spiking by increasing the spike afterhyperpolarization, allowing more Na+ channels to recover from inactivation which, by facilitating spike conduction, increased Ca2+influx in response to trains of stimuli (Klyachko et al., 2001).

Phosphorylation (phosphorylation) of cGMP in spike

2) Confidence 0.19 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2610389 Disease Relevance 0 Pain Relevance 0.15

Possibly, therefore, cGMP-dependent phosphorylation directly or indirectly inhibits the channels, resulting in enhanced GABA release.

Phosphorylation (phosphorylation) of cGMP associated with gaba

3) Confidence 0.19 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2610389 Disease Relevance 0 Pain Relevance 0.43

General Comments

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