INT257200
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Interestingly, Kv3 channels, which affect transmitter release by shaping the presynaptic action potential, have been found, when expressed in CHO cells, to be suppressed by the NOcGMP pathway, not through direct phosphorylation by PKG but through the intermediary of a phosphatase, which probably removes a phosphate group from the channel protein that normally promotes activity (Moreno et al., 2001). | |||||||||||||||
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Specifically, stimulation of Ca2+-activated K+ channels by cGMP-dependent phosphorylation enhanced presynaptic spiking by increasing the spike afterhyperpolarization, allowing more Na+ channels to recover from inactivation which, by facilitating spike conduction, increased Ca2+influx in response to trains of stimuli (Klyachko et al., 2001). | |||||||||||||||
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Possibly, therefore, cGMP-dependent phosphorylation directly or indirectly inhibits the channels, resulting in enhanced GABA release. | |||||||||||||||
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General Comments
This test has worked.