INT257202

Context Info Confidence 0.38 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 3 Disease Relevance 0.36 Pain Relevance 0.66

cytosol (Pde5a) signal transduction (Pde5a)

Anatomy Link Frequency astrocytes 1 Pde5a (Mus musculus)

Pain Link Frequency Relevance Heat long-term potentiation 119 99.38 Neurotransmitter 27 81.68 depression 27 73.12 GABAergic 15 59.64 Hippocampus 26 55.48 nMDA receptor 31 47.32 Pain 1 10.48 Central nervous system 23 5.00 Endocannabinoid 11 5.00 Serotonin 11 5.00

Disease Link Frequency Relevance Heat Depression 27 73.12 Cognitive Disorder 189 59.72 Injury 3 12.16 Pain 1 10.48 Targeted Disruption 33 5.00 Anxiety Disorder 24 5.00 Disease 14 5.00 Schizophrenia 12 5.00 Aging 12 5.00 Shock 10 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

As presynaptic cGMP plays a role in E-LTP, theoretically, inhibition of cGMP degradation with, for instance, a PDE9-I should, therefore, be able to influence L-LTP/LTM via E-LTP/STM as well.

Protein_catabolism (degradation) of cGMP associated with long-term potentiation

1) Confidence 0.38 Published 2008 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2704616 Disease Relevance 0.05 Pain Relevance 0.35

The slow kinetics of cGMP degradation in cerebellar astrocytes could mean that cGMP provides a time-averaged readout of ongoing synaptic activity.

Protein_catabolism (degradation) of cGMP in astrocytes

2) Confidence 0.31 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2610389 Disease Relevance 0 Pain Relevance 0.06

Taken together, treatment of rodents with different types of selective PDE-Is, which inhibit the degradation of the second messengers cAMP and/or cGMP, improved their STM as well as LTM.

Protein_catabolism (degradation) of cGMP

3) Confidence 0.25 Published 2008 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2704616 Disease Relevance 0.31 Pain Relevance 0.25

General Comments

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