INT257202

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Context Info
Confidence 0.38
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.36
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pde5a) signal transduction (Pde5a)
Anatomy Link Frequency
astrocytes 1
Pde5a (Mus musculus)
Pain Link Frequency Relevance Heat
long-term potentiation 119 99.38 Very High Very High Very High
Neurotransmitter 27 81.68 Quite High
depression 27 73.12 Quite High
GABAergic 15 59.64 Quite High
Hippocampus 26 55.48 Quite High
nMDA receptor 31 47.32 Quite Low
Pain 1 10.48 Low Low
Central nervous system 23 5.00 Very Low Very Low Very Low
Endocannabinoid 11 5.00 Very Low Very Low Very Low
Serotonin 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 27 73.12 Quite High
Cognitive Disorder 189 59.72 Quite High
Injury 3 12.16 Low Low
Pain 1 10.48 Low Low
Targeted Disruption 33 5.00 Very Low Very Low Very Low
Anxiety Disorder 24 5.00 Very Low Very Low Very Low
Disease 14 5.00 Very Low Very Low Very Low
Schizophrenia 12 5.00 Very Low Very Low Very Low
Aging 12 5.00 Very Low Very Low Very Low
Shock 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As presynaptic cGMP plays a role in E-LTP, theoretically, inhibition of cGMP degradation with, for instance, a PDE9-I should, therefore, be able to influence L-LTP/LTM via E-LTP/STM as well.
Protein_catabolism (degradation) of cGMP associated with long-term potentiation
1) Confidence 0.38 Published 2008 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2704616 Disease Relevance 0.05 Pain Relevance 0.35
The slow kinetics of cGMP degradation in cerebellar astrocytes could mean that cGMP provides a time-averaged readout of ongoing synaptic activity.
Protein_catabolism (degradation) of cGMP in astrocytes
2) Confidence 0.31 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2610389 Disease Relevance 0 Pain Relevance 0.06
Taken together, treatment of rodents with different types of selective PDE-Is, which inhibit the degradation of the second messengers cAMP and/or cGMP, improved their STM as well as LTM.
Protein_catabolism (degradation) of cGMP
3) Confidence 0.25 Published 2008 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2704616 Disease Relevance 0.31 Pain Relevance 0.25

General Comments

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