INT257210

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Context Info
Confidence 0.41
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.65
Pain Relevance 1.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gria2) endoplasmic reticulum (Gria2) plasma membrane (Gria2)
protein complex (Gria2)
Anatomy Link Frequency
spine 2
neurons 2
Gria2 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 21 99.98 Very High Very High Very High
long-term potentiation 38 99.78 Very High Very High Very High
Dorsal horn neuron 6 99.06 Very High Very High Very High
Inflammation 10 97.62 Very High Very High Very High
nMDA receptor 33 83.88 Quite High
depression 20 77.28 Quite High
Glutamate receptor 17 70.44 Quite High
Endocannabinoid 11 63.20 Quite High
Lasting pain 6 61.80 Quite High
Neuronal excitability 4 58.12 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 10 97.62 Very High Very High Very High
Depression 20 77.28 Quite High
Hypersensitivity 2 63.36 Quite High
Pain 9 61.80 Quite High
Nociception 26 59.92 Quite High
Neuropathic Pain 4 56.56 Quite High
Inflammatory Pain 9 55.56 Quite High
Autism 3 50.00 Quite Low
Cognitive Disorder 3 24.00 Low Low
Syndrome 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been demonstrated that complete Freund's adjuvant (CFA)-induced peripheral inflammation may induce synaptic GluR2 internalization in spinal dorsal horn neurons and this internalization was initiated by PKC-mediated GluR2 phosphorylation at Serine880.
Positive_regulation (mediated) of Phosphorylation (phosphorylation) of GluR2 in neurons associated with kinase c, inflammation and dorsal horn neuron
1) Confidence 0.41 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.39 Pain Relevance 0.54
Initial LTP is likely mediated by phosphorylation of AMPA receptors, and the initial spine expansion occurs in the absence of trafficking of AMPA receptors [54].
Positive_regulation (mediated) of Phosphorylation (phosphorylation) of AMPA in spine associated with long-term potentiation
2) Confidence 0.05 Published 2010 Journal Mol Autism Section Body Doc Link PMC3019144 Disease Relevance 0 Pain Relevance 0.22
This, together with ongoing protein kinase C activity, leads to persistent phosphorylation of AMPA receptors at a particular serine residue, which disrupts AMPA receptor clusters and favours receptor endocytosis (Launey et al., 2004; Steinberg et al., 2006).
Positive_regulation (leads) of Phosphorylation (phosphorylation) of AMPA associated with kinase c
3) Confidence 0.01 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2610389 Disease Relevance 0.25 Pain Relevance 0.31

General Comments

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