INT257213
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
For example, cerebellar Purkinje cells all appear to contain PDE5 but a subset additionally expresses a PDE1 isoform (Shimizu-Albergine et al., 2003); in cerebellar astrocytes PDE5 is also prominent but PDE4, which has low affinity (> 100 ? | |||||||||||||||
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A few selective inhibitors of PDE7 have now been identified (Giembycz 2005) and using these it is becoming clear that inhibition of PDE7A can regulate proinflammatory and immune cell function when used in associated with PDE4 inhibitors. | |||||||||||||||
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Siguazodan, a PDE3 inhibitor, potentiated relaxation induced by rolipram suggesting an interaction between PDE3 inhibition and PDE4 inhibition (Torphy et al 1993). | |||||||||||||||
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PDE3 differs from PDE4 in that it has high affinity for both cAMP and cGMP so that these substrates are mutually competitive and thus PDE3 hydrolysis of cAMP can be inhibited by cGMP. | |||||||||||||||
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PDE4 also forms another macromolecular signaling complex with ? | |||||||||||||||
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The R81X is a known functional mutation that codes for a truncated protein lacking the tetratricopeptide repeat (TPR) carboxy terminal domains, which are essential for AIP to bind to the aryl hydrocarbon receptor (AHR) and heat shock 90 (HSP90).12,27 Previous in vitro studies of the R81X mutation have shown that it blocks the interaction of wild type AIP and phosphodiesterase type 4A (PDE4A), potentially disrupting the cAMP cascade.28
AIP somatic status in the somatotropinoma, adrenocortical tumor and B-cell non-Hodgkin lymphoma | |||||||||||||||
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General Comments
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