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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.18
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Flvcr2) transmembrane transport (Flvcr2)
Anatomy Link Frequency
hypothalamus 1
PP2A 1
Flvcr2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Serotonin 12 100.00 Very High Very High Very High
monoamine 1 98.00 Very High Very High Very High
Neurotransmitter 13 97.00 Very High Very High Very High
Kinase C 18 91.80 High High
Hippocampus 8 90.52 High High
depression 11 85.88 High High
GABAergic 15 80.84 Quite High
gABA 9 72.52 Quite High
long-term potentiation 13 70.44 Quite High
Action potential 9 68.08 Quite High
Disease Link Frequency Relevance Heat
Obsessive-compulsive Disorder 1 90.60 High High
Depression 11 85.88 High High
Obesity 2 48.56 Quite Low
Disease 3 39.52 Quite Low
Increased Venous Pressure Under Development 4 38.24 Quite Low
Injury 3 12.40 Low Low
Stress 5 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low
Ganglion Cysts 3 5.00 Very Low Very Low Very Low
Cognitive Disorder 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, it has been found that PKG-dependent phosphorylation of a threonine residue on the serotonin transporter enhanced serotonin uptake (Ramamoorthy et al., 2007), an effect that may contribute to the lowering of extracellular serotonin brought about by the NO–cGMP pathway observed in the hypothalamus (Kaehler et al., 1999), and to obsessive–compulsive disorder in humans (Zhang et al., 2007a).
Phosphorylation (phosphorylation) of transporter in hypothalamus associated with obsessive-compulsive disorder and serotonin
1) Confidence 0.01 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2610389 Disease Relevance 0.18 Pain Relevance 0.57
Although it is not known whether PP2A binds directly to monoamine transporters, this association might help to explain the molecular events that are responsible for transporter phosphorylation and internalization


Phosphorylation (phosphorylation) of transporter in PP2A associated with monoamine
2) Confidence 0.01 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0.26

General Comments

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