INT257217

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.03
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pde2a, Pde5a) signal transduction (Pde2a, Pde5a) Golgi apparatus (Pde2a)
endoplasmic reticulum (Pde2a) plasma membrane (Pde2a) nucleus (Pde2a)
Anatomy Link Frequency
photoreceptor cells 1
Pde2a (Rattus norvegicus)
Pde5a (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 6 95.68 Very High Very High Very High
Central nervous system 15 53.20 Quite High
Hippocampus 8 51.28 Quite High
Thalamus 3 40.56 Quite Low
nMDA receptor 27 5.00 Very Low Very Low Very Low
GABAergic 15 5.00 Very Low Very Low Very Low
long-term potentiation 13 5.00 Very Low Very Low Very Low
Serotonin 11 5.00 Very Low Very Low Very Low
depression 11 5.00 Very Low Very Low Very Low
Endocannabinoid 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 11 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 4 5.00 Very Low Very Low Very Low
Injury 3 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low
Ganglion Cysts 3 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 2 5.00 Very Low Very Low Very Low
Shock 2 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 2 5.00 Very Low Very Low Very Low
Demyelinating Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Direct actions of cGMP can be exerted by binding to agonist or regulatory sites on cyclic nucleotide-gated (CNG) ion channels (reviewed in Kaupp & Seifert, 2002) or hyperpolarization-activated, cyclic nucleotide-modulated (HCN) channels (reviewed in Craven & Zagotta, 2006). cGMP also binds directly to the phosphodiesterase (PDE) enzymes PDE2, PDE5 and, in retinal photoreceptor cells, PDE6, resulting in heightened catalytic activity and cGMP breakdown. cGMP is a low-efficacy substrate for another PDE, PDE3, so that cGMP binding to the catalytic site leads to inhibition of cAMP hydrolysis, potentially raising cAMP levels (reviewed by Bender & Beavo, 2006).
PDE2 Binding (binds) of cGMP in photoreceptor cells associated with agonist
1) Confidence 0.03 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2610389 Disease Relevance 0 Pain Relevance 0.10

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox