INT257222

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Context Info
Confidence 0.07
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.14
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pde5a) signal transduction (Pde5a)
Anatomy Link Frequency
synapse 1
Ltp (Mus musculus)
Pde5a (Mus musculus)
Pain Link Frequency Relevance Heat
long-term potentiation 66 100.00 Very High Very High Very High
Action potential 9 97.76 Very High Very High Very High
Glutamate 9 86.88 High High
GABAergic 15 86.40 High High
Neurotransmitter 19 83.96 Quite High
medulla 2 81.96 Quite High
depression 19 75.84 Quite High
Hippocampus 17 67.20 Quite High
nMDA receptor 29 64.24 Quite High
Serotonin 11 43.68 Quite Low
Disease Link Frequency Relevance Heat
Depression 19 75.84 Quite High
Increased Venous Pressure Under Development 5 67.92 Quite High
Cognitive Disorder 95 50.00 Quite Low
Obsessive-compulsive Disorder 1 23.20 Low Low
Targeted Disruption 18 5.00 Very Low Very Low Very Low
Anxiety Disorder 12 5.00 Very Low Very Low Very Low
Disease 7 5.00 Very Low Very Low Very Low
Schizophrenia 6 5.00 Very Low Very Low Very Low
Aging 6 5.00 Very Low Very Low Very Low
Shock 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As presynaptic cGMP plays a role in E-LTP, theoretically, inhibition of cGMP degradation with, for instance, a PDE9-I should, therefore, be able to influence L-LTP/LTM via E-LTP/STM as well.
E-LTP Binding (role) of cGMP associated with long-term potentiation
1) Confidence 0.07 Published 2008 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2704616 Disease Relevance 0 Pain Relevance 0.35
LTP at the cerebellar mossy fibre–granule cell synapse, however, engaged the NO–cGMP pathway to increase the presynaptic terminal excitability (Maffei et al., 2003).
LTP Neg (NO) Binding (engaged) of cGMP in synapse associated with long-term potentiation
2) Confidence 0.02 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2610389 Disease Relevance 0.14 Pain Relevance 0.40

General Comments

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