INT257224

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Context Info
Confidence 0.03
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.09
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pde5a) mitochondrion (Creb1) signal transduction (Pde5a)
nucleus (Creb1) DNA binding (Creb1) transcription factor binding (Creb1)
Anatomy Link Frequency
intermediary 2
Pde5a (Mus musculus)
Creb1 (Mus musculus)
Pain Link Frequency Relevance Heat
long-term potentiation 13 94.88 High High
depression 11 91.72 High High
nMDA receptor 27 52.88 Quite High
Neurotransmitter 11 49.12 Quite Low
Glutamate 7 12.56 Low Low
Central nervous system 15 5.00 Very Low Very Low Very Low
GABAergic 15 5.00 Very Low Very Low Very Low
Serotonin 11 5.00 Very Low Very Low Very Low
Endocannabinoid 11 5.00 Very Low Very Low Very Low
Action potential 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 11 91.72 High High
Increased Venous Pressure Under Development 4 5.00 Very Low Very Low Very Low
Injury 3 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low
Ganglion Cysts 3 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 2 5.00 Very Low Very Low Very Low
Shock 2 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 2 5.00 Very Low Very Low Very Low
Demyelinating Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In slice preparations, it has been shown that NO–cGMP–PKG resulted in the phosphorylation of the transcription factor CREB (cAMP response element binding protein) in the cell bodies of postsynaptic neurones by a mechanism involving Ca2+ release from ryanodine-sensitive stores (Lu et al., 1999; Lu & Hawkins, 2002), implicating cyclic ADP ribose as an intermediary.
cGMP Positive_regulation (resulted) of Phosphorylation (phosphorylation) of CREB in intermediary
1) Confidence 0.03 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2610389 Disease Relevance 0.09 Pain Relevance 0.20

General Comments

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