INT257227

Context Info Confidence 0.01 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.33 Pain Relevance 0.05

signal transduction (Pik3cd, Akt1) kinase activity (Pik3cd, Akt1) cell differentiation (Pik3cd) transport (Akt1) aging (Akt1) enzyme binding (Akt1)

Pik3cd (Mus musculus) Akt1 (Mus musculus)

Pain Link Frequency Relevance Heat Kinase C 3 92.40 Hippocampus 8 26.80 Serotonin 11 5.20 nMDA receptor 27 5.00 Central nervous system 15 5.00 GABAergic 15 5.00 long-term potentiation 13 5.00 depression 11 5.00 Endocannabinoid 11 5.00 Neurotransmitter 11 5.00

Disease Link Frequency Relevance Heat Stress 2 98.48 Shock 2 83.24 Targeted Disruption 3 50.72 Depression 11 5.00 Increased Venous Pressure Under Development 4 5.00 Injury 3 5.00 Ganglion Cysts 3 5.00 Neurodegenerative Disease 2 5.00 Cv Unclassified Under Development 2 5.00 Demyelinating Disease 1 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The prototype kinase mediating serine-1179 phosphorylation is Akt, which is activated by phosphoinositide-3 kinase in response to stimuli such as shear stress, oestrogens, insulin and vascular endothelial growth factor, but the same site is also targeted by AMP kinase (in response to metabolic stress), protein kinase C, cAMP- and cGMP-dependent protein kinases, and CaMKII.

phosphoinositide-3 kinase Positive_regulation (activated) of Akt associated with stress and kinase c

1) Confidence 0.01 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2610389 Disease Relevance 0.33 Pain Relevance 0.05

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