INT257227

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.33
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pik3cd, Akt1) kinase activity (Pik3cd, Akt1) cell differentiation (Pik3cd)
transport (Akt1) aging (Akt1) enzyme binding (Akt1)
Pik3cd (Mus musculus)
Akt1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 3 92.40 High High
Hippocampus 8 26.80 Quite Low
Serotonin 11 5.20 Low Low
nMDA receptor 27 5.00 Very Low Very Low Very Low
Central nervous system 15 5.00 Very Low Very Low Very Low
GABAergic 15 5.00 Very Low Very Low Very Low
long-term potentiation 13 5.00 Very Low Very Low Very Low
depression 11 5.00 Very Low Very Low Very Low
Endocannabinoid 11 5.00 Very Low Very Low Very Low
Neurotransmitter 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 2 98.48 Very High Very High Very High
Shock 2 83.24 Quite High
Targeted Disruption 3 50.72 Quite High
Depression 11 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 4 5.00 Very Low Very Low Very Low
Injury 3 5.00 Very Low Very Low Very Low
Ganglion Cysts 3 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 2 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 2 5.00 Very Low Very Low Very Low
Demyelinating Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The prototype kinase mediating serine-1179 phosphorylation is Akt, which is activated by phosphoinositide-3 kinase in response to stimuli such as shear stress, oestrogens, insulin and vascular endothelial growth factor, but the same site is also targeted by AMP kinase (in response to metabolic stress), protein kinase C, cAMP- and cGMP-dependent protein kinases, and CaMKII.


phosphoinositide-3 kinase Positive_regulation (activated) of Akt associated with stress and kinase c
1) Confidence 0.01 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2610389 Disease Relevance 0.33 Pain Relevance 0.05

General Comments

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