INT257229

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.17
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PRKG1, Pde5a) signal transduction (PRKG1, Pde5a) plasma membrane (PRKG1)
cytoplasm (PRKG1)
Anatomy Link Frequency
neuromuscular junction 1
PRKG1 (Homo sapiens)
Pde5a (Mus musculus)
Pain Link Frequency Relevance Heat
Endocannabinoid 11 96.58 Very High Very High Very High
Neurotransmitter 11 88.48 High High
depression 11 79.12 Quite High
GABAergic 15 78.00 Quite High
agonist 6 70.00 Quite High
Serotonin 11 67.12 Quite High
Cannabinoid 3 53.68 Quite High
Peripheral nervous system 1 38.72 Quite Low
nMDA receptor 27 5.00 Very Low Very Low Very Low
Central nervous system 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Graves' Ophthalmopathy 1 92.96 High High
Depression 11 79.12 Quite High
Increased Venous Pressure Under Development 4 5.00 Very Low Very Low Very Low
Injury 3 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low
Ganglion Cysts 3 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 2 5.00 Very Low Very Low Very Low
Shock 2 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the vertebrate (lizard) neuromuscular junction, endocannabinoid release underlay the transient suppression of acetylcholine release produced by activation of muscarinic (M3) receptors but, in order for the pathway to be effective, NO–cGMP and associated PKG were needed (Newman et al., 2007).
PKG Binding (associated) of cGMP in neuromuscular junction associated with endocannabinoid
1) Confidence 0.01 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2610389 Disease Relevance 0.17 Pain Relevance 0.41

General Comments

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