INT257231

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Context Info
Confidence 0.07
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.07
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PRKG1) signal transduction (PRKG1) plasma membrane (PRKG1)
cytoplasm (PRKG1)
Anatomy Link Frequency
adult mouse 1
PRKG1 (Homo sapiens)
Ltp (Mus musculus)
Pain Link Frequency Relevance Heat
long-term potentiation 13 100.00 Very High Very High Very High
nMDA receptor 27 77.04 Quite High
depression 11 74.00 Quite High
Glutamate 7 36.72 Quite Low
Hippocampus 8 18.32 Low Low
Endocannabinoid 11 12.56 Low Low
Central nervous system 15 5.00 Very Low Very Low Very Low
GABAergic 15 5.00 Very Low Very Low Very Low
Serotonin 11 5.00 Very Low Very Low Very Low
Neurotransmitter 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 11 74.00 Quite High
Increased Venous Pressure Under Development 4 5.00 Very Low Very Low Very Low
Injury 3 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low
Ganglion Cysts 3 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 2 5.00 Very Low Very Low Very Low
Shock 2 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 2 5.00 Very Low Very Low Very Low
Demyelinating Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, Serulle et al. (2007) were able show that blocking PKGII selectively using a dominant negative fragment also reduced LTP in adult mouse hippocampal slices, indicating that the mechanism may not be confined to the relatively immature circuitry of the tissue culture model.
PKG Negative_regulation (reduced) of LTP in adult mouse associated with long-term potentiation
1) Confidence 0.07 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2610389 Disease Relevance 0.07 Pain Relevance 0.20

General Comments

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