INT257234

Context Info Confidence 0.12 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.19

plasma membrane (GRIN1, Camk2a) kinase activity (Camk2a) cytoplasm (Camk2a)

Anatomy Link Frequency synapses 1 GRIN1 (Homo sapiens) Camk2a (Mus musculus)

Pain Link Frequency Relevance Heat nMDA receptor 27 100.00 Kinase C 3 85.08 Glutamate 7 78.08 Neurotransmitter 11 44.92 Central nervous system 15 18.68 GABAergic 15 5.00 long-term potentiation 13 5.00 Serotonin 11 5.00 depression 11 5.00 Endocannabinoid 11 5.00

Disease Link Frequency Relevance Heat Depression 11 5.00 Increased Venous Pressure Under Development 4 5.00 Injury 3 5.00 Targeted Disruption 3 5.00 Ganglion Cysts 3 5.00 Neurodegenerative Disease 2 5.00 Shock 2 5.00 Stress 2 5.00 Cv Unclassified Under Development 2 5.00 Demyelinating Disease 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

CaMKII, a co-resident with NMDA receptors and nNOS at synapses (Kennedy, 2000), was found to phosphorylate the enzyme on serine-847 and inhibit NO formation by ?

NMDA Binding (resident) of CaMKII in synapses associated with nmda receptor

1) Confidence 0.12 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2610389 Disease Relevance 0 Pain Relevance 0.19

General Comments

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