INT257273

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Context Info
Confidence 0.35
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.20
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP26A1) endoplasmic reticulum (CYP26A1)
CYP26A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 3 5.00 Very Low Very Low Very Low
fibrosis 3 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
pain pelvic 1 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 3 98.76 Very High Very High Very High
Rheumatoid Arthritis 24 98.38 Very High Very High Very High
Uterine Fibroids 120 95.44 Very High Very High Very High
Papillomavirus Infection 3 9.92 Low Low
Cancer 9 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low
Pulmonary Fibrosis 2 5.00 Very Low Very Low Very Low
Adhesions 2 5.00 Very Low Very Low Very Low
Leukemia 2 5.00 Very Low Very Low Very Low
Reprotox - General 1 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RA regulates a number of genes involved in the RA pathway including the receptors and metabolizing enzymes such as CYP26.12–14 Up-regulation of CYP26A1 expression protects many cell types from apoptosis.15 We have previously demonstrated that CYP26 genes were up-regulated in leiomyomas as compared to myometrial tissue.6 Untreated leiomyoma cells (0 µm) demonstrated a 16·8 ± 4·5-fold up-regulation (P < 0·05) of CYP26A1 gene expression compared with myometrial cells (Table 1).
Positive_regulation (regulation) of Gene_expression (expression) of CYP26A1 associated with uterine fibroids, rheumatoid arthritis and apoptosis
1) Confidence 0.35 Published 2008 Journal Clinical Endocrinology Section Body Doc Link PMC2610401 Disease Relevance 1.20 Pain Relevance 0

General Comments

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