INT257283

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Context Info
Confidence 0.03
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.41
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (COL5A2) molecular_function (COL5A2)
Anatomy Link Frequency
cartilage 2
COL5A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 34 96.10 Very High Very High Very High
Osteoarthritis 46 78.88 Quite High
rheumatoid arthritis 2 64.20 Quite High
cINOD 2 35.28 Quite Low
Pain 2 11.04 Low Low
cytokine 9 5.00 Very Low Very Low Very Low
metalloproteinase 5 5.00 Very Low Very Low Very Low
fibrosis 3 5.00 Very Low Very Low Very Low
agonist 3 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Uterine Fibroids 120 96.36 Very High Very High Very High
INFLAMMATION 38 96.10 Very High Very High Very High
Osteoarthritis 46 78.88 Quite High
Myeloid Leukemia 8 71.44 Quite High
Rheumatoid Arthritis 26 64.20 Quite High
Apoptosis 11 61.92 Quite High
Death 2 40.32 Quite Low
Toxicity 2 32.08 Quite Low
Arthropathy 2 14.88 Low Low
Pain 2 11.04 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
With ATRA treatment, a down-regulation of collagen genes was observed.
Negative_regulation (down) of Negative_regulation (regulation) of collagen
1) Confidence 0.03 Published 2008 Journal Clinical Endocrinology Section Body Doc Link PMC2610401 Disease Relevance 0.73 Pain Relevance 0
As shown in Figure 4d, resveratrol treatment prevented AGEs-mediated decreases of collagen II by Western blotting.
Negative_regulation (prevented) of Negative_regulation (decreases) of collagen
2) Confidence 0.01 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2990994 Disease Relevance 0.20 Pain Relevance 0.06
Such anti-inflammatory properties of resveratrol could be faithfully reflected by detecting the degradation of proteoglycan and aggrecan as well as the suppression of proteoglycan release from cartilage explants, the inhibition of collagen II decrease and the attenuation of MMP expression and enzyme activity induced by AGEs (summarized in Figure 6).
Negative_regulation (inhibition) of Negative_regulation (decrease) of collagen in cartilage associated with inflammation
3) Confidence 0.01 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2990994 Disease Relevance 0.48 Pain Relevance 0.18

General Comments

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