INT257288

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Context Info
Confidence 0.21
First Reported 2008
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.52
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (COL5A2) molecular_function (COL5A2)
Anatomy Link Frequency
tendon 2
COL5A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 46 99.16 Very High Very High Very High
Inflammation 15 93.36 High High
metalloproteinase 7 69.04 Quite High
Infliximab 40 48.08 Quite Low
COX2 52 5.00 Very Low Very Low Very Low
Osteoarthritis 35 5.00 Very Low Very Low Very Low
diclofenac 34 5.00 Very Low Very Low Very Low
fibrosis 12 5.00 Very Low Very Low Very Low
agonist 9 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Posterior Tibial Tendon Dysfunction 25 99.92 Very High Very High Very High
Uterine Fibroids 360 99.84 Very High Very High Very High
INFLAMMATION 15 93.36 High High
Rheumatoid Arthritis 72 81.96 Quite High
Stress 11 74.96 Quite High
Foot Deformities 3 65.00 Quite High
Cirrhosis 10 62.36 Quite High
Rupture 10 61.12 Quite High
Adhesions 8 60.08 Quite High
Cancer 35 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fibrillogenesis in posterior tibial tendon dysfunction is altered due to higher expression of types III and V collagen and a decreased amount of collagen type I, which renders the originating fibrils structurally less resistant to mechanical forces.



Regulation (altered) of Gene_expression (expression) of collagen in tendon associated with posterior tibial tendon dysfunction
1) Confidence 0.21 Published 2008 Journal Clinics Section Abstract Doc Link PMC2664193 Disease Relevance 0.44 Pain Relevance 0
The synthesis of collagen is a hallmark of the strict regulation of MFs by a complex cytokine environment.
Regulation (regulation) of Gene_expression (synthesis) of collagen associated with cytokine
2) Confidence 0.09 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875629 Disease Relevance 0.09 Pain Relevance 0.22
induced proliferation and significant inhibition of contractile forces in MFs in the collagen gels, we did not find a significant inhibition of ?
Regulation (proliferation) of Gene_expression (gels) of collagen
3) Confidence 0.09 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875629 Disease Relevance 0.18 Pain Relevance 0.14
Chondrogenic differentiation and the SOX9 dependency of aggrecan and collagen expression may also be differentially modulated by these transcriptional cofactors under different tonicities.
Spec (may) Regulation (modulated) of Gene_expression (expression) of collagen
4) Confidence 0.06 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911888 Disease Relevance 0.14 Pain Relevance 0
Leiomyomas are characterized by excessive collagen production in the ECM.7,16 We therefore evaluated the effect of ATRA treatment on collagen production in leiomyoma cell cultures by measuring salt soluble collagen secreted into the media after 24 h of ATRA treatment, prior to one cycle of cell division.
Regulation (effect) of Gene_expression (production) of collagen associated with uterine fibroids
5) Confidence 0.03 Published 2008 Journal Clinical Endocrinology Section Body Doc Link PMC2610401 Disease Relevance 0.94 Pain Relevance 0
We found that mRNA expression of this collagen was unaffected by exposure to ATRA treatment (Table 1).
Neg (unaffected) Regulation (unaffected) of Gene_expression (expression) of collagen
6) Confidence 0.03 Published 2008 Journal Clinical Endocrinology Section Body Doc Link PMC2610401 Disease Relevance 0.59 Pain Relevance 0
Soluble collagen expression
Regulation (Soluble) of Gene_expression (expression) of collagen
7) Confidence 0.03 Published 2008 Journal Clinical Endocrinology Section Body Doc Link PMC2610401 Disease Relevance 0.14 Pain Relevance 0

General Comments

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