INT257290

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Context Info
Confidence 0.27
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.64
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (COL1A1) extracellular region (COL1A1) cytoplasm (COL1A1)
Anatomy Link Frequency
cartilage 2
lung 2
COL1A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 6 99.54 Very High Very High Very High
Kinase C 2 65.44 Quite High
agonist 6 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
pain pelvic 2 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Uterine Fibroids 240 99.84 Very High Very High Very High
Pulmonary Fibrosis 4 99.54 Very High Very High Very High
Sprains And Strains 26 83.44 Quite High
Adhesions 10 69.12 Quite High
Leukemia 4 51.28 Quite High
Targeted Disruption 1 34.96 Quite Low
Rheumatoid Arthritis 48 29.76 Quite Low
Cancer 18 23.16 Low Low
Fibrosis 2 22.00 Low Low
Disease 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In cultured stellate cells, it has been demonstrated that ATRA can prevent morphological transition towards a myofibroblast phenotype and decrease collagen 1 synthesis.37 In addition, ATRA can inhibit radiation-induced pulmonary fibrosis.39 The authors report inhibition of COL1A1 mRNA expression by ATRA in irradiated lung tissue.
Negative_regulation (inhibition) of Transcription (expression) of COL1A1 in lung associated with fibrosis and pulmonary fibrosis
1) Confidence 0.27 Published 2008 Journal Clinical Endocrinology Section Body Doc Link PMC2610401 Disease Relevance 0.62 Pain Relevance 0.13
Taken together, ATRA exposure reduced COL1A1 and COL4A1 mRNA expression in leiomyoma cells, approaching expression patterns comparable to myometrial cells.
Negative_regulation (reduced) of Transcription (expression) of COL1A1 associated with uterine fibroids
2) Confidence 0.27 Published 2008 Journal Clinical Endocrinology Section Body Doc Link PMC2610401 Disease Relevance 0.59 Pain Relevance 0
The most striking finding was that the mRNA expression of collagen type I, collagen type III, and tenascin-C in mechanically stimulated gels were all significantly upregulated compared to static controls and approached native T/L expression, and that bone and cartilage markers were not upregulated.
Negative_regulation (approached) of Transcription (expression) of collagen type I in cartilage
3) Confidence 0.10 Published 2010 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC2939640 Disease Relevance 0.44 Pain Relevance 0

General Comments

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