INT257291

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Context Info
Confidence 0.75
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 4.04
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP26A1) endoplasmic reticulum (CYP26A1)
Anatomy Link Frequency
endothelial cells 1
CYP26A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 13 49.52 Quite Low
agonist 12 21.04 Low Low
Kinase C 15 9.60 Low Low
antagonist 11 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
pain pelvic 4 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
endometriosis 1 5.00 Very Low Very Low Very Low
Dismenorea 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Uterine Fibroids 480 99.26 Very High Very High Very High
Apoptosis 12 98.76 Very High Very High Very High
Rheumatoid Arthritis 96 98.10 Very High Very High Very High
Leukemia 8 97.68 Very High Very High Very High
Cancer 37 67.24 Quite High
Pulmonary Fibrosis 8 50.32 Quite High
Tuberous Sclerosis 4 11.04 Low Low
Papillomavirus Infection 12 9.36 Low Low
Disease 12 5.00 Very Low Very Low Very Low
Reprotox - General 1 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example SAT1 gene expression was enhanced from a 5.9 fold increase to a 7.5 fold increase, whereas cytochrome P450, family 26, subfamily A, polypeptide 1 (CYP26A1) gene expression was repressed from an 18.0 fold increase to a 12.3 fold increase.
Gene_expression (expression) of CYP26A1
1) Confidence 0.75 Published 2010 Journal Cell Signal Section Body Doc Link PMC2791881 Disease Relevance 0 Pain Relevance 0
RA regulates a number of genes involved in the RA pathway including the receptors and metabolizing enzymes such as CYP26.12–14 Up-regulation of CYP26A1 expression protects many cell types from apoptosis.15 We have previously demonstrated that CYP26 genes were up-regulated in leiomyomas as compared to myometrial tissue.6 Untreated leiomyoma cells (0 µm) demonstrated a 16·8 ± 4·5-fold up-regulation (P < 0·05) of CYP26A1 gene expression compared with myometrial cells (Table 1).
Gene_expression (expression) of CYP26A1 associated with uterine fibroids, rheumatoid arthritis and apoptosis
2) Confidence 0.58 Published 2008 Journal Clinical Endocrinology Section Body Doc Link PMC2610401 Disease Relevance 1.13 Pain Relevance 0
RA regulates a number of genes involved in the RA pathway including the receptors and metabolizing enzymes such as CYP26.12–14 Up-regulation of CYP26A1 expression protects many cell types from apoptosis.15 We have previously demonstrated that CYP26 genes were up-regulated in leiomyomas as compared to myometrial tissue.6 Untreated leiomyoma cells (0 µm) demonstrated a 16·8 ± 4·5-fold up-regulation (P < 0·05) of CYP26A1 gene expression compared with myometrial cells (Table 1).
Gene_expression (expression) of CYP26A1 associated with uterine fibroids, rheumatoid arthritis and apoptosis
3) Confidence 0.58 Published 2008 Journal Clinical Endocrinology Section Body Doc Link PMC2610401 Disease Relevance 1.20 Pain Relevance 0
Various investigators have found a dose-dependent up-regulation of CYP26A1 by ATRA in different cell types.12,13 In leukaemia cells, ATRA can induce CYP26A1 at doses of 1 µm,12 whereas in endothelial cells, 10 µm ATRA was required to induce expression of CYP26A1.13 Our results demonstrated that CYP26A1 transcripts were up-regulated in myometrial cells exposed to ATRA when compared to unexposed cells.
Gene_expression (expression) of CYP26A1 in endothelial cells associated with leukemia
4) Confidence 0.51 Published 2008 Journal Clinical Endocrinology Section Body Doc Link PMC2610401 Disease Relevance 0.92 Pain Relevance 0
Significant up-regulation of CYP26A1 in myometrial cells and down-regulation in leiomyoma cells resulted in approximate equal levels of CYP26A1 in these cells at 10?
Gene_expression (levels) of CYP26A1 associated with uterine fibroids
5) Confidence 0.51 Published 2008 Journal Clinical Endocrinology Section Body Doc Link PMC2610401 Disease Relevance 0.80 Pain Relevance 0

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