INT257298

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Context Info
Confidence 0.19
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.03
Pain Relevance 2.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pde5a) signal transduction (Pde5a)
Anatomy Link Frequency
blood 2
spinal cord 2
Pde5a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antinociception 33 99.68 Very High Very High Very High
Spinal cord 2 98.76 Very High Very High Very High
Acute pain 6 89.12 High High
Analgesic 3 87.92 High High
Neuropathic pain 38 84.36 Quite High
Hyperalgesia 14 83.32 Quite High
intrathecal 21 82.48 Quite High
allodynia 16 81.76 Quite High
Cold hyperalgesia 2 80.88 Quite High
Pain 21 80.52 Quite High
Disease Link Frequency Relevance Heat
Hypotension 2 99.98 Very High Very High Very High
Nociception 11 97.40 Very High Very High Very High
Pressure Volume 2 Under Development 2 94.50 High High
Pain 25 89.12 High High
Neuropathic Pain 62 84.36 Quite High
Hyperalgesia 16 83.32 Quite High
Increased Venous Pressure Under Development 5 72.20 Quite High
Disease 4 67.20 Quite High
Injury 8 66.72 Quite High
Diabetic Neuropathy 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, it is conceivable that the increased cGMP level by inhibition of phosphodiesterase may contribute to the antinociception in the spinal cord.
Spec (may) Regulation (contribute) of Positive_regulation (increased) of cGMP in spinal cord associated with antinociception and spinal cord
1) Confidence 0.19 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610640 Disease Relevance 0.58 Pain Relevance 0.71
Oral sildenafil moderately reduced blood pressure in normal humans.35 Furthermore, a significant decrease of blood pressure was transiently observed with intravenous sildenafil in healthy men, whereas HR was not affected.36 Particularly, the combination of sildenafil with nitric oxide donors can potentiate the hypotensive effect by accumulation of cGMP.37 Therefore, the concomitant use of sildenafil with any drug which serves as a nitric oxide donor is absolutely contraindicated in clinics.38
Regulation (effect) of Positive_regulation (accumulation) of cGMP in blood associated with pressure volume 2 under development and hypotension
2) Confidence 0.11 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2799976 Disease Relevance 0.34 Pain Relevance 0.42
Guanylyl cyclase catalyzes the formation of cyclic guanosine monophosphate (cGMP) from GTP, leading to the synthesis of cGMP, whereas cGMP-specific phosphodiesterase catalyzes the hydrolysis of cGMP to GMP.2 Accordingly, intracellular cGMP concentrations are regulated by the action of guanylyl cyclase and the rate of degradation by cGMP-specific phosphodiesterase.6,7
Regulation (regulated) of Positive_regulation (concentrations) of cGMP
3) Confidence 0.11 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2799976 Disease Relevance 1.11 Pain Relevance 1.41

General Comments

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