INT257304

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Context Info
Confidence 0.15
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.48
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pde5a) signal transduction (Pde5a) plasma membrane (Oprd1)
cytoplasm (Oprd1) signal transducer activity (Oprd1)
Pde5a (Rattus norvegicus)
Oprd1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 12 100.00 Very High Very High Very High
Antinociceptive 7 96.44 Very High Very High Very High
Morphine 36 94.32 High High
narcan 9 93.32 High High
Opioid 3 92.08 High High
Pain 13 89.28 High High
antinociception 13 80.56 Quite High
depression 1 79.36 Quite High
intrathecal 21 50.00 Quite Low
Spinal cord 2 45.32 Quite Low
Disease Link Frequency Relevance Heat
Pain 19 89.28 High High
Vomiting 1 81.20 Quite High
Respiratory Failure 1 80.32 Quite High
Nociception 11 72.00 Quite High
Hyperalgesia 4 5.00 Very Low Very Low Very Low
Neuropathic Pain 4 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low
Overdose 1 5.00 Very Low Very Low Very Low
Erectile Dysfunction 1 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, it has not been known what increased cGMP by sildenafil could exert on opioid receptor, further research including receptor binding study will be necessary.
cGMP Positive_regulation (exert) of opioid receptor associated with opioid receptor
1) Confidence 0.15 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610640 Disease Relevance 0.48 Pain Relevance 0.89

General Comments

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