INT257314

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Context Info
Confidence 0.47
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.22
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Cyba) mitochondrion (Cyba) oxidoreductase activity (Cyba)
Golgi apparatus (Cyba) cytoplasm (Cyba)
Cyba (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 8 78.28 Quite High
fibrosis 4 62.48 Quite High
anesthesia 4 6.16 Low Low
antagonist 4 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 16 99.52 Very High Very High Very High
Hypertrophy 10 96.08 Very High Very High Very High
Stroke 2 95.08 Very High Very High Very High
Hypertension 28 90.76 High High
Fibrosis 6 78.96 Quite High
INFLAMMATION 8 78.28 Quite High
Cardiovascular Disorder Under Development 8 66.60 Quite High
Coronary Heart Disease 6 61.96 Quite High
Respiratory Sounds 2 59.76 Quite High
Targeted Disruption 2 59.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The overactivity of NAD(P)H oxidase, a major determinant of vascular tissue redox state, is associated with upregulation of p22phox mRNA, a major subunit of the enzyme, which results in impaired NO-dependent relaxation and media hypertrophy in SHR (13), stroke-prone SHR (SHRsp) (14, 15), DOCA-salt rat (16), angiotensin II-treated rats (17, 18), or aldosterone hypertensive rat (9, 19).
Positive_regulation (upregulation) of p22phox associated with hypertrophy, stroke and hypertension
1) Confidence 0.47 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610641 Disease Relevance 0.62 Pain Relevance 0.03
Aldosterone has a direct effect on oxidative stress through its ability to increase the levels of p22phox, an major subunit of NAD(P)H oxidase, essential for superoxide anion generation (9, 11).
Positive_regulation (increase) of p22phox associated with stress
2) Confidence 0.47 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610641 Disease Relevance 0.60 Pain Relevance 0.08

General Comments

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