INT257315

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Context Info
Confidence 0.47
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 4.04
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Cyba) mitochondrion (Cyba) oxidoreductase activity (Cyba)
Golgi apparatus (Cyba) cytoplasm (Cyba)
Anatomy Link Frequency
smooth muscle 6
phagocyte 2
Cyba (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Central nervous system 1 88.28 High High
fibrosis 13 84.56 Quite High
Pain 1 79.60 Quite High
Inflammation 26 74.56 Quite High
antagonist 12 64.16 Quite High
Bioavailability 4 34.96 Quite Low
tolerance 2 15.84 Low Low
anesthesia 13 5.00 Very Low Very Low Very Low
ketamine 6 5.00 Very Low Very Low Very Low
Restless leg syndrome 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 6 100.00 Very High Very High Very High
Neutrophil Disorders 79 99.96 Very High Very High Very High
Diabetes Mellitus 47 98.92 Very High Very High Very High
Hypertrophy 30 94.52 High High
Hypertension 87 91.72 High High
Injury 18 87.36 High High
Stroke 6 85.92 High High
Fibrosis 19 84.56 Quite High
Proteinuria 6 82.96 Quite High
Necrosis 6 80.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, we demonstrated that aldosterone activated NAD(P)H oxidase and increased the expression of membrane-bound elements (p22phox and gp91phox) and cytosolic components (p47phox) of the enzyme, which may be linked to cardio-vascular-renal damage.
Positive_regulation (increased) of Gene_expression (expression) of p22phox
1) Confidence 0.47 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610641 Disease Relevance 0.53 Pain Relevance 0.03
Although p22phox alone does not support superoxide production but it has been clearly shown to stabilize the expression of gp91phox (20) and Nox1 (21) in culture, probably serving as a stabilizing and/or regulatory subunit. p22phox overexpression in transgenic (Tg) mice (Tgp22smc) that overexpress the p22phox subunit of NAD(P)H oxidase selectively in smooth muscle, concomitantly upregulates Nox1, and potentates angiotensin II induced vascular hypertrophy (22).
Positive_regulation (overexpress) of Gene_expression (overexpress) of p22phox in smooth muscle associated with targeted disruption and hypertrophy
2) Confidence 0.34 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610641 Disease Relevance 0.51 Pain Relevance 0
Although p22phox alone does not support superoxide production but it has been clearly shown to stabilize the expression of gp91phox (20) and Nox1 (21) in culture, probably serving as a stabilizing and/or regulatory subunit. p22phox overexpression in transgenic (Tg) mice (Tgp22smc) that overexpress the p22phox subunit of NAD(P)H oxidase selectively in smooth muscle, concomitantly upregulates Nox1, and potentates angiotensin II induced vascular hypertrophy (22).
Positive_regulation (overexpression) of Gene_expression (overexpression) of p22phox in smooth muscle associated with targeted disruption and hypertrophy
3) Confidence 0.34 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610641 Disease Relevance 0.51 Pain Relevance 0
Although p22phox alone does not support superoxide production but it has been clearly shown to stabilize the expression of gp91phox (20) and Nox1 (21) in culture, probably serving as a stabilizing and/or regulatory subunit. p22phox overexpression in transgenic (Tg) mice (Tgp22smc) that overexpress the p22phox subunit of NAD(P)H oxidase selectively in smooth muscle, concomitantly upregulates Nox1, and potentates angiotensin II induced vascular hypertrophy (22).
Positive_regulation (overexpression) of Gene_expression (overexpression) of p22phox in smooth muscle associated with targeted disruption and hypertrophy
4) Confidence 0.34 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610641 Disease Relevance 0.51 Pain Relevance 0
The p22phox may individually interact with cytosolic regulatory elements, p47phox and Rac-1, and therefore, both increased expression of p22phox and p47phox will lead to activation of the enzyme.
Positive_regulation (increased) of Gene_expression (expression) of p22phox
5) Confidence 0.32 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610641 Disease Relevance 0.23 Pain Relevance 0
Aortic expression of the subunits p47phox, gp91phox, and p22phox increased in aldosterone-infused rats by 5.5, 4.7, and 3.2-fold, respectively, which was decreased completely by spironolactone and partially by losartan and apocynin.
Positive_regulation (increased) of Gene_expression (expression) of p22phox
6) Confidence 0.32 Published 2008 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2610641 Disease Relevance 0.32 Pain Relevance 0
Etoh et al. reported that the expression of both Nox4 and p22phox were increased in a STZ-induced model of diabetes [8].
Positive_regulation (increased) of Gene_expression (expression) of p22phox associated with diabetes mellitus
7) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909910 Disease Relevance 0.48 Pain Relevance 0
The enzyme that catalyzes the respiratory burst, the leukocyte NADPH oxidase, consists of subunits, four of which are important for CGD (designated phox for phagocyte oxidase): gp91phox (or Nox2) and p22phox, located in membranes, as well as two cytosolic oxidase components, p47phox and p67phox.
Positive_regulation (designated) of Gene_expression (oxidase) of phagocyte in phagocyte associated with neutrophil disorders
8) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2668749 Disease Relevance 0.95 Pain Relevance 0.20

General Comments

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