INT257316

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.52
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cybb) Golgi apparatus (Cybb) endoplasmic reticulum (Cybb)
plasma membrane (Cybb) intracellular (Cybb) cytoplasm (Cybb)
Anatomy Link Frequency
brainstem 1
Cybb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
medulla 7 96.16 Very High Very High Very High
gABA 14 82.88 Quite High
fibrosis 6 69.12 Quite High
antagonist 8 16.96 Low Low
Inflammation 12 5.00 Very Low Very Low Very Low
Glutamate 9 5.00 Very Low Very Low Very Low
anesthesia 7 5.00 Very Low Very Low Very Low
ketamine 6 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Neuronal excitability 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chronic Renal Failure 37 99.32 Very High Very High Very High
Pressure And Volume Under Development 14 98.04 Very High Very High Very High
Renal Disease 1 88.12 High High
Hypertension 48 79.20 Quite High
Stress 35 71.76 Quite High
Fibrosis 9 69.12 Quite High
Hyperplasia 3 66.24 Quite High
Necrosis 3 64.68 Quite High
Cancer 3 64.32 Quite High
Hypertrophy 15 50.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Spironolactone and losartan significantly decreased p47phox, gp91phox, and p22phox mRNA expression.
Transcription (expression) of gp91phox
1) Confidence 0.02 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610641 Disease Relevance 0 Pain Relevance 0
Similarly, aldosterone infusion showed elevated renal tissue ROS levels which were associated with increased mRNA expression of p22phox, Nox-4, and gp91phox (10).
Transcription (expression) of gp91phox
2) Confidence 0.02 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610641 Disease Relevance 0.39 Pain Relevance 0.03
Spironolactone significantly decreased p47phox and gp91phox mRNA expression.
Transcription (expression) of gp91phox
3) Confidence 0.02 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610641 Disease Relevance 0 Pain Relevance 0
In CRF rats we found an increase in the abundance of p47phox and gp91phox mRNA within the RVLM associated with a reduction of Ang II type 1 receptors (AT1) mRNA in the brainstem compared to controls (C).
Transcription (abundance) of gp91phox in brainstem associated with medulla and chronic renal failure
4) Confidence 0.01 Published 2010 Journal International Journal of Hypertension Section Abstract Doc Link PMC3022169 Disease Relevance 1.13 Pain Relevance 0.13

General Comments

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