INT257322

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Context Info
Confidence 0.33
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.13
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Ncf1) cytosol (Ncf1) Golgi apparatus (Ncf1)
plasma membrane (Ncf1) cytoplasm (Ncf1)
Anatomy Link Frequency
brainstem 1
Ncf1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
medulla 7 95.64 Very High Very High Very High
gABA 14 81.84 Quite High
fibrosis 4 25.76 Quite Low
Glutamate 9 5.00 Very Low Very Low Very Low
Inflammation 8 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
ketamine 5 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Neuronal excitability 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chronic Renal Failure 37 99.32 Very High Very High Very High
Pressure And Volume Under Development 14 98.04 Very High Very High Very High
Renal Disease 1 88.12 High High
Stress 27 70.72 Quite High
Hypertension 34 50.00 Quite Low
Cardiovascular Disorder Under Development 8 50.00 Quite Low
Body Weight 2 43.56 Quite Low
Coronary Heart Disease 6 27.68 Quite Low
Fibrosis 6 25.76 Quite Low
Hypertrophy 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Spironolactone and losartan significantly decreased p47phox, gp91phox, and p22phox mRNA expression.
Transcription (expression) of p47phox
1) Confidence 0.33 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610641 Disease Relevance 0 Pain Relevance 0
In CRF rats we found an increase in the abundance of p47phox and gp91phox mRNA within the RVLM associated with a reduction of Ang II type 1 receptors (AT1) mRNA in the brainstem compared to controls (C).
Transcription (abundance) of p47phox in brainstem associated with medulla and chronic renal failure
2) Confidence 0.27 Published 2010 Journal International Journal of Hypertension Section Abstract Doc Link PMC3022169 Disease Relevance 1.13 Pain Relevance 0.13
Spironolactone significantly decreased p47phox and gp91phox mRNA expression.
Transcription (expression) of p47phox
3) Confidence 0.14 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610641 Disease Relevance 0 Pain Relevance 0

General Comments

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