INT257326

Context Info Confidence 0.33 First Reported 2008 Last Reported 2011 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 1.21 Pain Relevance 0.03

cell proliferation (Ncf1) cytosol (Ncf1) Golgi apparatus (Ncf1) plasma membrane (Ncf1) cytoplasm (Ncf1)

Anatomy Link Frequency aorta 1 Ncf1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat fibrosis 2 51.20 Inflammation 16 50.00 Inflammatory response 7 5.00 cytokine 6 5.00 anesthesia 4 5.00 Bioavailability 4 5.00 antagonist 3 5.00 tolerance 2 5.00 Restless leg syndrome 1 5.00 ketamine 1 5.00

Disease Link Frequency Relevance Heat Hyperoxia 23 95.84 Hyperglycemia 13 94.84 Diabetes Mellitus 47 85.48 Lung Injury 12 65.76 Urological Neuroanatomy 9 63.20 Stress 13 62.56 Bronchopulmonary Dysplasia 15 60.32 Adhesions 3 56.56 Coronary Heart Disease 4 53.12 Fibrosis 3 51.20

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Protein

Mutation

Event

Anatomy

Negation

Speculation

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Disease term

Chronic hyperglycemia did not increased expression of several components of the NAD(P)H oxidase system and this was observed at both the protein and mRNA levels These results are similar to the Zucker fa/fa/rat (type 2) but differ from that observed by Bitnar et.al who observed increases in p47phox in younger GK rats [8], [51], [52].

Positive_regulation (increases) of p47phox associated with hyperglycemia

1) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909910 Disease Relevance 0.52 Pain Relevance 0

Immunostaining showed a significant increase in p47phox in the whole aorta of aldosterone-salt rat compared with that of control (Fig. 4A).

Positive_regulation (increase) of p47phox in aorta

2) Confidence 0.29 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610641 Disease Relevance 0.10 Pain Relevance 0.03

Hyperoxia-induced production of ROS was evaluated by NADPH oxidase activation, because NADPH oxidase produces oxygen free radicals both in phagocytic20 and nonphagocytic cells.21 Exposure to oxygen (HC) significantly increased p67phox both in the cytosolic and membrane fractions, indicating activation of NADPH oxidase, compared to the normoxia groups (NC and NG) in Western blot analyses, and the G-CSF (HG) significantly attenuated this hyperoxia-induced NADPH oxidase activation (Fig. 7).

Positive_regulation (increased) of p67phox associated with hyperoxia

3) Confidence 0.22 Published 2011 Journal Yonsei Medical Journal Section Body Doc Link PMC3017710 Disease Relevance 0.58 Pain Relevance 0

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