INT257326

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Context Info
Confidence 0.33
First Reported 2008
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.21
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Ncf1) cytosol (Ncf1) Golgi apparatus (Ncf1)
plasma membrane (Ncf1) cytoplasm (Ncf1)
Anatomy Link Frequency
aorta 1
Ncf1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fibrosis 2 51.20 Quite High
Inflammation 16 50.00 Quite Low
Inflammatory response 7 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Bioavailability 4 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
Restless leg syndrome 1 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperoxia 23 95.84 Very High Very High Very High
Hyperglycemia 13 94.84 High High
Diabetes Mellitus 47 85.48 High High
Lung Injury 12 65.76 Quite High
Urological Neuroanatomy 9 63.20 Quite High
Stress 13 62.56 Quite High
Bronchopulmonary Dysplasia 15 60.32 Quite High
Adhesions 3 56.56 Quite High
Coronary Heart Disease 4 53.12 Quite High
Fibrosis 3 51.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic hyperglycemia did not increased expression of several components of the NAD(P)H oxidase system and this was observed at both the protein and mRNA levels These results are similar to the Zucker fa/fa/rat (type 2) but differ from that observed by Bitnar et.al who observed increases in p47phox in younger GK rats [8], [51], [52].
Positive_regulation (increases) of p47phox associated with hyperglycemia
1) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909910 Disease Relevance 0.52 Pain Relevance 0
Immunostaining showed a significant increase in p47phox in the whole aorta of aldosterone-salt rat compared with that of control (Fig. 4A).
Positive_regulation (increase) of p47phox in aorta
2) Confidence 0.29 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610641 Disease Relevance 0.10 Pain Relevance 0.03
Hyperoxia-induced production of ROS was evaluated by NADPH oxidase activation, because NADPH oxidase produces oxygen free radicals both in phagocytic20 and nonphagocytic cells.21 Exposure to oxygen (HC) significantly increased p67phox both in the cytosolic and membrane fractions, indicating activation of NADPH oxidase, compared to the normoxia groups (NC and NG) in Western blot analyses, and the G-CSF (HG) significantly attenuated this hyperoxia-induced NADPH oxidase activation (Fig. 7).


Positive_regulation (increased) of p67phox associated with hyperoxia
3) Confidence 0.22 Published 2011 Journal Yonsei Medical Journal Section Body Doc Link PMC3017710 Disease Relevance 0.58 Pain Relevance 0

General Comments

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