INT257329

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 16
Disease Relevance 8.38
Pain Relevance 7.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 1
blood 1
endothelial cells 1
aorta 1
kidney 1
RT1-O2-ps (Rattus norvegicus)
Pain Link Frequency Relevance Heat
B1 receptor 1092 99.98 Very High Very High Very High
agonist 180 99.84 Very High Very High Very High
allodynia 252 99.48 Very High Very High Very High
Pain 74 99.16 Very High Very High Very High
bradykinin 158 98.68 Very High Very High Very High
antagonist 160 96.30 Very High Very High Very High
Spinal cord 132 95.84 Very High Very High Very High
Inflammatory response 20 90.48 High High
Inflammation 164 86.52 High High
Inflammatory mediators 12 84.40 Quite High
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 236 99.78 Very High Very High Very High
Neuropathy 48 99.76 Very High Very High Very High
Neuropathic Pain 312 99.48 Very High Very High Very High
Insulin Resistance 156 99.32 Very High Very High Very High
Pain 62 99.16 Very High Very High Very High
Stress 426 98.12 Very High Very High Very High
Congenital Anomalies 36 94.16 High High
INFLAMMATION 202 90.12 High High
Diabetes Mellitus 204 88.64 High High
Diabetes Complications 48 86.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased production of O2•?
Gene_expression (production) of O2
1) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935380 Disease Relevance 1.42 Pain Relevance 0.74
The one-week treatment with SSR240612 normalised the higher production of O2•?
Gene_expression (production) of O2
2) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935380 Disease Relevance 0.09 Pain Relevance 0.46
Experiments designed to study the source of O2•?
Gene_expression (source) of O2
3) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935380 Disease Relevance 0 Pain Relevance 0.19
The source of O2•?
Gene_expression (source) of O2
4) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935380 Disease Relevance 1.13 Pain Relevance 0.70
The production of O2•?
Gene_expression (production) of O2
5) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935380 Disease Relevance 0.06 Pain Relevance 0.34
The production of O2•?
Gene_expression (production) of O2
6) Confidence 0.02 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2935380 Disease Relevance 1.02 Pain Relevance 0.69
Glucose-fed rats displayed higher plasma levels of glucose and insulin, insulin resistance, arterial hypertension, enhanced production of superoxide anion (O2•?)
Gene_expression (production) of O2 in plasma associated with pressure and volume under development and insulin resistance
7) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935380 Disease Relevance 1.32 Pain Relevance 1.17
A selective B1R antagonist (SSR240612) was administered acutely (3–30 mg/kg) or daily for a period of 7 days (10 mg/kg) and the impact was measured on systolic blood pressure, allodynia, protein and/or mRNA B1R expression, aortic superoxide anion (O2•?)
Gene_expression (expression) of O2 in blood associated with allodynia, antagonist and b1 receptor
8) Confidence 0.02 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2935380 Disease Relevance 1.12 Pain Relevance 0.57
The intraperitoneal administration of Sar[D-Phe8]des-Arg9-BK (1 mg/kg) in 8-week glucose-fed rats also enhanced by 4-fold the production of O2•?
Gene_expression (production) of O2 associated with bradykinin
9) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935380 Disease Relevance 0 Pain Relevance 0.53
Similarly to the in vitro protocol, systemic treatment with apocynin (50 mg/kg) abolished the effect of the B1R agonist on the production of O2•?.
Gene_expression (production) of O2 associated with b1 receptor and agonist
10) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935380 Disease Relevance 0 Pain Relevance 0.51
This statement is supported by the increased production of O2•?
Gene_expression (production) of O2
11) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935380 Disease Relevance 0.56 Pain Relevance 0.36
To further substantiate the contribution of B1R in the production of O2•?
Gene_expression (production) of O2 associated with b1 receptor
12) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935380 Disease Relevance 0 Pain Relevance 0.53
These findings are consistent with the concept that the translocation of p47phox to membrane is involved in the overall activation of NDA(P)H oxidase, resulting in O2- production in aorta and kidney.
Gene_expression (production) of O2 in kidney
13) Confidence 0.01 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610641 Disease Relevance 0.37 Pain Relevance 0.03
Moreover, in endothelial cells, adenovirus-mediated expression of O2?
Gene_expression (expression) of O2 in endothelial cells
14) Confidence 0.01 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2879545 Disease Relevance 0.61 Pain Relevance 0.24
Increased levels of O2?
Gene_expression (levels) of O2
15) Confidence 0.01 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2879545 Disease Relevance 0.30 Pain Relevance 0.15
These findings are consistent with the concept that the translocation of p47phox to membrane is involved in the overall activation of NDA(P)H oxidase, resulting in O2- production in aorta and kidney.
Gene_expression (production) of O2 in aorta
16) Confidence 0.01 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610641 Disease Relevance 0.37 Pain Relevance 0.03

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