INT257331

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Context Info
Confidence 0.33
First Reported 2008
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 2.39
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Ncf1) cytosol (Ncf1) Golgi apparatus (Ncf1)
plasma membrane (Ncf1) cytoplasm (Ncf1)
Anatomy Link Frequency
kidney 4
lung 2
Ncf1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fibrosis 10 83.60 Quite High
antagonist 12 68.00 Quite High
Inflammation 44 50.00 Quite Low
Inflammatory response 14 40.72 Quite Low
Inflammatory mediators 2 40.72 Quite Low
cytokine 12 36.52 Quite Low
anesthesia 12 5.00 Very Low Very Low Very Low
ketamine 5 5.00 Very Low Very Low Very Low
dexamethasone 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperoxia 46 99.84 Very High Very High Very High
Injury 15 87.36 High High
Coronary Heart Disease 15 85.52 High High
Fibrosis 15 83.60 Quite High
Proteinuria 5 82.96 Quite High
Stress 44 80.32 Quite High
Bronchopulmonary Dysplasia 30 79.96 Quite High
Hypertrophy 25 79.68 Quite High
Hypertension 70 76.28 Quite High
Urological Neuroanatomy 18 75.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, increased expression of the p67phox protein was observed both in the cytosolic and membrane fraction in HC, and G-CSF treatment significantly attenuated hyperoxia-induced NADPH oxidase activation as evidenced by reduced membrane translocation of the p67phox in the lung tissue.
Positive_regulation (increased) of Gene_expression (expression) of p67phox in lung associated with hyperoxia
1) Confidence 0.33 Published 2011 Journal Yonsei Medical Journal Section Body Doc Link PMC3017710 Disease Relevance 0.72 Pain Relevance 0
Increased expression of p47phox in aldosterone-infused rat by immunohistochemistry
Positive_regulation (Increased) of Gene_expression (expression) of p47phox
2) Confidence 0.29 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610641 Disease Relevance 0 Pain Relevance 0
Spironolactone, losartan, and apocynin inhibited the aldosterone-stimulated p47phox expression in kidney (Fig. 4B).


Positive_regulation (stimulated) of Gene_expression (expression) of p47phox in kidney
3) Confidence 0.29 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610641 Disease Relevance 0.24 Pain Relevance 0.04
The p47phox expression enhanced in kidney of aldosterone infused rats compared with that of control rats.
Positive_regulation (enhanced) of Gene_expression (expression) of p47phox in kidney
4) Confidence 0.29 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610641 Disease Relevance 0.20 Pain Relevance 0.04
The aldosterone-induced p47phox overexpression was prevented by spironolactone, and partially by losartan and apocynin.
Positive_regulation (overexpression) of Gene_expression (overexpression) of p47phox
5) Confidence 0.29 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610641 Disease Relevance 0.13 Pain Relevance 0.03
Furthermore, we demonstrated that aldosterone activated NAD(P)H oxidase and increased the expression of membrane-bound elements (p22phox and gp91phox) and cytosolic components (p47phox) of the enzyme, which may be linked to cardio-vascular-renal damage.
Positive_regulation (increased) of Gene_expression (expression) of p47phox
6) Confidence 0.27 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610641 Disease Relevance 0.59 Pain Relevance 0.03
When NADPH oxidase is activated, expression and membrane translocation of a cytosolic subunit of NADPH oxidase p67phox is increased.
Positive_regulation (increased) of Gene_expression (expression) of p67phox
7) Confidence 0.24 Published 2011 Journal Yonsei Medical Journal Section Body Doc Link PMC3017710 Disease Relevance 0.52 Pain Relevance 0

General Comments

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