INT257334

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Context Info
Confidence 0.53
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 5.39
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Cyba) mitochondrion (Cyba) oxidoreductase activity (Cyba)
Golgi apparatus (Cyba) cytoplasm (Cyba)
Anatomy Link Frequency
smooth muscle 3
plasma 1
phagocyte 1
kidney 1
Cyba (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Central nervous system 1 87.48 High High
fibrosis 21 83.76 Quite High
Pain 1 78.80 Quite High
Inflammation 42 77.76 Quite High
antagonist 20 64.16 Quite High
Bioavailability 4 34.96 Quite Low
tolerance 2 15.84 Low Low
anesthesia 21 6.16 Low Low
ketamine 10 5.00 Very Low Very Low Very Low
Restless leg syndrome 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 10 100.00 Very High Very High Very High
Neutrophil Disorders 79 99.56 Very High Very High Very High
Stress 83 99.26 Very High Very High Very High
Diabetes Mellitus 47 98.32 Very High Very High Very High
Necrosis 10 94.92 High High
Cancer 10 94.56 High High
Hypertrophy 50 94.52 High High
Hypertension 143 91.72 High High
Injury 30 86.80 High High
Stroke 10 85.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, we demonstrated that aldosterone activated NAD(P)H oxidase and increased the expression of membrane-bound elements (p22phox and gp91phox) and cytosolic components (p47phox) of the enzyme, which may be linked to cardio-vascular-renal damage.
Gene_expression (expression) of p22phox
1) Confidence 0.53 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610641 Disease Relevance 0.53 Pain Relevance 0.03
Although p22phox alone does not support superoxide production but it has been clearly shown to stabilize the expression of gp91phox (20) and Nox1 (21) in culture, probably serving as a stabilizing and/or regulatory subunit. p22phox overexpression in transgenic (Tg) mice (Tgp22smc) that overexpress the p22phox subunit of NAD(P)H oxidase selectively in smooth muscle, concomitantly upregulates Nox1, and potentates angiotensin II induced vascular hypertrophy (22).
Gene_expression (overexpress) of p22phox in smooth muscle associated with targeted disruption and hypertrophy
2) Confidence 0.46 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610641 Disease Relevance 0.51 Pain Relevance 0
Although p22phox alone does not support superoxide production but it has been clearly shown to stabilize the expression of gp91phox (20) and Nox1 (21) in culture, probably serving as a stabilizing and/or regulatory subunit. p22phox overexpression in transgenic (Tg) mice (Tgp22smc) that overexpress the p22phox subunit of NAD(P)H oxidase selectively in smooth muscle, concomitantly upregulates Nox1, and potentates angiotensin II induced vascular hypertrophy (22).
Gene_expression (overexpression) of p22phox in smooth muscle associated with targeted disruption and hypertrophy
3) Confidence 0.46 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610641 Disease Relevance 0.51 Pain Relevance 0
Although p22phox alone does not support superoxide production but it has been clearly shown to stabilize the expression of gp91phox (20) and Nox1 (21) in culture, probably serving as a stabilizing and/or regulatory subunit. p22phox overexpression in transgenic (Tg) mice (Tgp22smc) that overexpress the p22phox subunit of NAD(P)H oxidase selectively in smooth muscle, concomitantly upregulates Nox1, and potentates angiotensin II induced vascular hypertrophy (22).
Gene_expression (overexpression) of p22phox in smooth muscle associated with targeted disruption and hypertrophy
4) Confidence 0.46 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610641 Disease Relevance 0.51 Pain Relevance 0
Aortic expression of the subunits p47phox, gp91phox, and p22phox increased in aldosterone-infused rats by 5.5, 4.7, and 3.2-fold, respectively, which was decreased completely by spironolactone and partially by losartan and apocynin.
Gene_expression (expression) of p22phox
5) Confidence 0.41 Published 2008 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2610641 Disease Relevance 0.32 Pain Relevance 0
In the present study, we have shown that aldosterone treatment induced overexpression of two membrane-bound elements (p22phox and gp91phox) and one cytosolic component (p47phox) of the NAD(P)H oxidase and its activity, and led to the translocation of the cytosolic p47phox to the plasma membrane in aorta and kidney.
Gene_expression (overexpression) of p22phox in plasma
6) Confidence 0.41 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610641 Disease Relevance 0.39 Pain Relevance 0
The p22phox may individually interact with cytosolic regulatory elements, p47phox and Rac-1, and therefore, both increased expression of p22phox and p47phox will lead to activation of the enzyme.
Gene_expression (expression) of p22phox
7) Confidence 0.41 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610641 Disease Relevance 0.23 Pain Relevance 0
Aldosterone has a direct effect on oxidative stress through its ability to increase the levels of p22phox, an major subunit of NAD(P)H oxidase, essential for superoxide anion generation (9, 11).
Gene_expression (levels) of p22phox associated with stress
8) Confidence 0.41 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610641 Disease Relevance 0.60 Pain Relevance 0.08
Similarly, aldosterone infusion showed elevated renal tissue ROS levels which were associated with increased mRNA expression of p22phox, Nox-4, and gp91phox (10).
Gene_expression (expression) of p22phox
9) Confidence 0.41 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610641 Disease Relevance 0.39 Pain Relevance 0.03
In kidney, aldosterone-salt rats showed significantly higher p47phox, gp91phox, and p22phox expression than that of control rats.
Gene_expression (expression) of p22phox in kidney
10) Confidence 0.41 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610641 Disease Relevance 0 Pain Relevance 0
Etoh et al. reported that the expression of both Nox4 and p22phox were increased in a STZ-induced model of diabetes [8].
Gene_expression (expression) of p22phox associated with diabetes mellitus
11) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909910 Disease Relevance 0.47 Pain Relevance 0
The enzyme that catalyzes the respiratory burst, the leukocyte NADPH oxidase, consists of subunits, four of which are important for CGD (designated phox for phagocyte oxidase): gp91phox (or Nox2) and p22phox, located in membranes, as well as two cytosolic oxidase components, p47phox and p67phox.
Gene_expression (oxidase) of phagocyte in phagocyte associated with neutrophil disorders
12) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2668749 Disease Relevance 0.94 Pain Relevance 0.20

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