INT25739

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.50
First Reported 1986
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 1.34
Pain Relevance 2.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Chrng)
Anatomy Link Frequency
spinal cord 1
cerebral cortex 1
brain 1
external 1
tail vein 1
Chrng (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 4 100.00 Very High Very High Very High
Clonidine 6 99.18 Very High Very High Very High
agonist 12 98.58 Very High Very High Very High
dorsal root ganglion 2 97.72 Very High Very High Very High
Neurotransmitter 1 97.12 Very High Very High Very High
cerebral cortex 3 95.72 Very High Very High Very High
potassium channel 6 95.60 Very High Very High Very High
tetrodotoxin 3 94.00 High High
midbrain 3 89.16 High High
antagonist 3 87.44 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 2 97.72 Very High Very High Very High
Neuroleptic Malignant Syndrome 12 88.80 High High
Nociception 8 84.80 Quite High
Tremor 1 82.00 Quite High
Ocular Toxicity (including Many Sub-types) 1 81.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BM 123 was injected into the tail vein of Sprague-Dawley rats, reducing mAChR to approximately 10% of normal as judged by [3H](-)QNB binding.
Negative_regulation (reducing) of mAChR in tail vein
1) Confidence 0.50 Published 1986 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 3097716 Disease Relevance 0.23 Pain Relevance 0.13
Also, the protein levels of the mAChR subtypes in the spinal cord were significantly down-regulated by siRNA treatment, as determined by the immunoprecipitation and receptor-binding assay.
Negative_regulation (down-regulated) of mAChR in spinal cord associated with spinal cord
2) Confidence 0.39 Published 2009 Journal J. Neurochem. Section Abstract Doc Link 19780895 Disease Relevance 0.62 Pain Relevance 0.49
It thus appears that mAChR regulation in the rat cerebral cortex is linked to changes in active K+-channel currents: activation of the K+-channel by depolarization-induced changes in K+ current or by agonist stimulation leading to changes in the selective K+ currents stimulate mAChR down-regulation; blockage of the K+-channels prevents this down-regulation.
Negative_regulation (down-regulation) of mAChR in cerebral cortex associated with agonist and cerebral cortex
3) Confidence 0.37 Published 1989 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 2538705 Disease Relevance 0.11 Pain Relevance 0.24
However, a common thread linking the various agents which induce mAChR down-regulation appears to involve changes in potassium (K+) current.
Negative_regulation (down-regulation) of mAChR
4) Confidence 0.32 Published 1989 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 2538705 Disease Relevance 0.24 Pain Relevance 0.35
Depolarization of neural membranes for 4 h at 22-37 degrees C using veratridine or high external potassium (K+) led to a temperature-dependent down-regulation of surface mAChR of 26.2% and 11.3%.
Negative_regulation (down-regulation) of mAChR in external
5) Confidence 0.32 Published 1989 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 2538705 Disease Relevance 0.14 Pain Relevance 0.27
Thus, marked reduction in the levels of brain ChE is not the only factor involved in the production of mAChR downregulation to cholinesterase inhibitors.
Negative_regulation (downregulation) of mAChR in brain
6) Confidence 0.06 Published 1993 Journal Brain Res. Bull. Section Abstract Doc Link 8221166 Disease Relevance 0 Pain Relevance 0.21
Clonidine pretreatment reversed the soman-induced mAChR downregulation in cortex and hindbrain produced by acute soman administration.
Negative_regulation (downregulation) of mAChR in hindbrain associated with clonidine
7) Confidence 0.04 Published 1993 Journal Brain Res. Bull. Section Abstract Doc Link 8221166 Disease Relevance 0 Pain Relevance 0.22
Clonidine pretreatment reversed the soman-induced mAChR downregulation in cortex and hindbrain produced by acute soman administration.
Negative_regulation (downregulation) of mAChR in cortex associated with clonidine
8) Confidence 0.02 Published 1993 Journal Brain Res. Bull. Section Abstract Doc Link 8221166 Disease Relevance 0 Pain Relevance 0.22

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox