INT257406

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Context Info
Confidence 0.46
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.60
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (TNFRSF1A) extracellular region (TNFRSF1A) plasma membrane (TNFRSF1A)
nucleus (TNFRSF1A) protein complex (TNFRSF1A)
TNFRSF1A (Homo sapiens)
Pain Link Frequency Relevance Heat
Adalimumab 75 87.92 High High
rheumatoid arthritis 12 86.88 High High
Inflammation 32 84.04 Quite High
cytokine 10 83.80 Quite High
methotrexate 5 73.52 Quite High
Arthritis 20 66.36 Quite High
Inflammatory marker 4 60.00 Quite High
Infliximab 14 51.60 Quite High
anakinra 18 50.00 Quite Low
Pain 3 20.32 Low Low
Disease Link Frequency Relevance Heat
Syndrome 7 97.16 Very High Very High Very High
Tumor Necrosis Factor Receptor-associated Periodic Syndrome 1 95.04 Very High Very High Very High
Cryopyrin-associated Periodic Syndromes 1 94.04 High High
Castlemans Disease 1 92.48 High High
Hyperplasia 1 90.04 High High
Uveitis 52 88.92 High High
Disease 37 87.64 High High
Rheumatoid Arthritis 12 86.88 High High
INFLAMMATION 34 84.04 Quite High
Rheumatic Diseases 5 82.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This has been demonstrated in patients who were treated with a recombinant protein generated by fusing the p55 TNF-?
Localization (generated) of p55
1) Confidence 0.46 Published 2010 Journal Middle East African Journal of Ophthalmology Section Body Doc Link PMC2991444 Disease Relevance 0.81 Pain Relevance 0.37
For immuno-precipitation of TNFR1, equal amounts of pre-cleared cell lysates were incubated in Tris–HCl buffer, pH 7.4, containing 50 mM NaCl, 1 mM EDTA, 1 mM EGTA, 1% (w/v) Triton X-100, and 0.5% (w/v) Nonidet P-40, with 2 ?
Localization (precipitation) of TNFR1
2) Confidence 0.34 Published 2010 Journal Cellular Signalling Section Body Doc Link PMC2806525 Disease Relevance 0 Pain Relevance 0
Mutations were not found in the coding regions of MVK, TNFRSF1A, and NLRP3 (previously NALP3/CIAS1) making the diagnoses of Hyper IgD syndrome, TNF receptor associated periodic syndrome (TRAPS), and Muckle Wells/Familial Cold Urticaria all unlikely.
Localization (regions) of TNFRSF1A associated with cryopyrin-associated periodic syndromes, tumor necrosis factor receptor-associated periodic syndrome and syndrome
3) Confidence 0.29 Published 2008 Journal Cases J Section Body Doc Link PMC2612653 Disease Relevance 1.78 Pain Relevance 0.18

General Comments

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