INT257418

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Context Info
Confidence 0.43
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.93
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Snca) mitochondrion (Snca) histone binding (Snca)
plasma membrane (Snca) cytoskeleton (Snca) nucleus (Snca)
Anatomy Link Frequency
cortex 3
hippocampus 1
Snca (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 63 99.44 Very High Very High Very High
Substantia nigra 12 33.64 Quite Low
Dopamine 6 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
Paracetamol 3 5.00 Very Low Very Low Very Low
Serotonin 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuroblastoma 3 83.64 Quite High
Disease 63 69.96 Quite High
Dementia 9 55.04 Quite High
Parkinson's Disease 27 54.52 Quite High
Cognitive Disorder 3 29.88 Quite Low
Multiple System Atrophy 9 19.48 Low Low
Alzheimer's Dementia 6 9.72 Low Low
Hypersensitivity 6 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Toxicity 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the absence of plasmid co-transfection, quantitative RT-PCR showed that the endogenous SNCA mRNA transcript was reduced by 89% for Mayo 2, 52% for Mayo 7 and 67% for Mayo 8 (Additional file 3).
Negative_regulation (reduced) of Transcription (transcript) of SNCA
1) Confidence 0.43 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2612658 Disease Relevance 0.08 Pain Relevance 0
We then injected them into the Cornu Ammonis (CA1) of the hippocampus of mice and demonstrated a reduction in SNCA mRNA levels by quantitative reverse transcription-polymerase chain reaction (RT-PCR) and in situ hybridization throughout the hippocampus and cortex.
Negative_regulation (reduction) of Transcription (levels) of SNCA in cortex associated with hippocampus
2) Confidence 0.43 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2612658 Disease Relevance 0.42 Pain Relevance 0.10
We then injected them into the Cornu Ammonis (CA1) of the hippocampus of mice and demonstrated a reduction in SNCA mRNA levels by quantitative reverse transcription-polymerase chain reaction (RT-PCR) and in situ hybridization throughout the hippocampus and cortex.
Negative_regulation (reduction) of in hippocampus Transcription (levels) of SNCA in cortex associated with hippocampus
3) Confidence 0.15 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2612658 Disease Relevance 0.42 Pain Relevance 0.10

General Comments

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