INT257447

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Context Info
Confidence 0.08
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 4.68
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein folding (TBCE) cytoskeleton (TBCE) cytoplasm (TBCE)
Anatomy Link Frequency
tear 2
liver 1
impression 1
TBCE (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 54 100.00 Very High Very High Very High
Inflammation 114 99.98 Very High Very High Very High
cytokine 54 99.00 Very High Very High Very High
alcohol 5 96.88 Very High Very High Very High
Bile 5 64.48 Quite High
Inflammatory response 16 61.56 Quite High
imagery 3 48.68 Quite Low
ischemia 4 12.08 Low Low
corticosteroid 8 8.64 Low Low
fibrosis 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sjoegrens Syndrome 53 100.00 Very High Very High Very High
Disorders Of The Lacrimal System 27 100.00 Very High Very High Very High
Ocular & Orbital Inflammation 1 99.98 Very High Very High Very High
Disease 85 98.00 Very High Very High Very High
Injury 31 96.08 Very High Very High Very High
Organ Transplantation 2 94.64 High High
Hypersensitivity 6 89.08 High High
INFLAMMATION 128 87.40 High High
Age-related Macular Degeneration 64 86.20 High High
Dry Eye 130 85.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Restasis has been a prescription drug in the US since April 2003 when it was approved by the FDA for patients whose tear production is presumed to be suppressed due to ocular inflammation associated with KCS.
KCS Binding (associated) of in tear associated with disorders of the lacrimal system, inflammation and ocular & orbital inflammation
1) Confidence 0.08 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699789 Disease Relevance 1.19 Pain Relevance 0.15
Pre-screening for KCS and NDE subjects was performed within two months of the actual clinic visit for collection of tears and impression cytology specimens.
KCS Binding (screening) of in impression associated with sjoegrens syndrome
2) Confidence 0.07 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2613075 Disease Relevance 1.04 Pain Relevance 0
Binding of LPS to CD14/TLR4 on KCs activates production of cytokines and oxidants, primary mediators of early ethanol-induced liver injury.
KCs Binding (Binding) of in liver associated with injury, agonist and cytokine
3) Confidence 0.06 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 1.10 Pain Relevance 0.51
One concern might be whether inheritance of HRD will affect gene therapy potential; for example, STGD is recessive and the mutations give variable penetration and expressivity.
HRD Spec (whether) Binding (inheritance) of associated with disease
4) Confidence 0.03 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2962903 Disease Relevance 0.32 Pain Relevance 0
Pre-screening for KCS and NDE subjects was performed within two months of the actual clinic visit for collection of tears and impression cytology specimens.
KCS Binding (screening) of in tears associated with sjoegrens syndrome
5) Confidence 0.02 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2613075 Disease Relevance 1.04 Pain Relevance 0

General Comments

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