INT25745

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Context Info
Confidence 0.45
First Reported 1988
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 0.25
Pain Relevance 3.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Tspo) aging (Tspo) response to stress (Tspo)
Anatomy Link Frequency
neurons 1
Tspo (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 11 100.00 Very High Very High Very High
gABA 9 100.00 Very High Very High Very High
Analgesic 4 100.00 Very High Very High Very High
Versed 9 99.92 Very High Very High Very High
antidepressant 6 99.88 Very High Very High Very High
Endogenous opioid 1 98.88 Very High Very High Very High
Antinociceptive 6 98.48 Very High Very High Very High
halothane 8 98.40 Very High Very High Very High
agonist 4 95.88 Very High Very High Very High
anesthesia 1 93.08 High High
Disease Link Frequency Relevance Heat
Pain 2 87.00 High High
Nociception 1 84.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of benzodiazepine receptor antagonism by flumazenil on the MAC of halothane in the rat.
Regulation (effect) of benzodiazepine receptor associated with versed and halothane
1) Confidence 0.45 Published 1989 Journal Anesthesiology Section Title Doc Link 2539028 Disease Relevance 0 Pain Relevance 0.74
To better understand antidepressant drug effects on the GABA(A) receptor complex (the GABA(A) receptor, chloride ionophore and benzodiazepine receptor), we investigated how antidepressants influenced power spectrum changes induced by pentylenetetrazol (PTZ), a chloride ionophore antagonist, in the rat hippocampal electroencephalogram (EEG).
Regulation (effects) of benzodiazepine receptor associated with gaba, antidepressant and antagonist
2) Confidence 0.35 Published 2000 Journal Neuropsychobiology Section Abstract Doc Link 11015033 Disease Relevance 0 Pain Relevance 0.49
It is, therefore, proposed that the intrinsic action induced by RO 15-1788 is exerted via the indirect activation of endogenous opioid systems and that the observed effect is not due to the action of the antagonist on the benzodiazepine receptor.
Regulation (action) of benzodiazepine receptor associated with antagonist and endogenous opioid
3) Confidence 0.27 Published 1988 Journal Eur. J. Pharmacol. Section Abstract Doc Link 3127226 Disease Relevance 0.08 Pain Relevance 0.90
Participation of the GABA/benzodiazepine receptor and the NO-cyclicGMP pathway in the "antinociceptive-like effects" of diazepam.
Regulation (Participation) of GABA/benzodiazepine receptor associated with gaba, analgesic and antinociceptive
4) Confidence 0.18 Published 2008 Journal Pharmacol. Biochem. Behav. Section Title Doc Link 18638499 Disease Relevance 0.17 Pain Relevance 0.61
These data are consistent with recent biochemical studies indicating that chronic ethanol treatment modulates the GABAA-benzodiazepine-ionophore receptor complex by altering the expression of specific molecular components and inhibiting the activity of the receptor complex.
Regulation (modulates) of GABAA-benzodiazepine-ionophore
5) Confidence 0.16 Published 1993 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 8385785 Disease Relevance 0 Pain Relevance 0.37
CONCLUSIONS: Midazolam augmented both the duration of GABA-mediated synaptic current and the amplitude of GABA-induced current by acting on the GABA(A)-benzodiazepine receptor in substantia gelatinosa neurons; this would increase the inhibitory GABAergic transmission.
Regulation (acting) of benzodiazepine receptor in neurons
6) Confidence 0.09 Published 2000 Journal Anesthesiology Section Body Doc Link 10691239 Disease Relevance 0 Pain Relevance 0

General Comments

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