INT257475

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Context Info
Confidence 0.47
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.12
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Pir) nucleus (Pir) cytoplasm (Pir)
Anatomy Link Frequency
neural 1
Pir (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 8 28.84 Quite Low
GABAergic 2 20.12 Low Low
antagonist 9 5.00 Very Low Very Low Very Low
agonist 8 5.00 Very Low Very Low Very Low
Thalamus 4 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
HCN1 2 5.00 Very Low Very Low Very Low
Action potential 2 5.00 Very Low Very Low Very Low
hyperexcitability 1 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Tremor 116 96.36 Very High Very High Very High
Movement Disorders 2 73.28 Quite High
Dystonia 1 64.64 Quite High
Neurological Disease 2 5.00 Very Low Very Low Very Low
Aging 2 5.00 Very Low Very Low Very Low
Disease 1 5.00 Very Low Very Low Very Low
Epilepsy 1 5.00 Very Low Very Low Very Low
Syndrome 1 5.00 Very Low Very Low Very Low
Convulsion 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
By increasing specific membrane conductances that are known to increase PIR and neural excitability, such as Ih and IT, we could simulate the range of frequencies of tremor recorded from ET patients.


Positive_regulation (increase) of PIR in neural associated with tremor
1) Confidence 0.47 Published 2008 Journal J Transl Med Section Body Doc Link PMC2613385 Disease Relevance 1.12 Pain Relevance 0

General Comments

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