INT257502

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Context Info
Confidence 0.36
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.98
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (MC3R) signal transducer activity (MC3R)
Anatomy Link Frequency
MC3 1
MC3R (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 3 99.84 Very High Very High Very High
cytokine 13 98.36 Very High Very High Very High
Neuropeptide 2 72.24 Quite High
Bioavailability 9 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
potassium channel 3 5.00 Very Low Very Low Very Low
Action potential 3 5.00 Very Low Very Low Very Low
analgesia 2 5.00 Very Low Very Low Very Low
Buprenorphine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Reperfusion Injury 1 92.88 High High
Disease 18 91.00 High High
Appetite Loss 45 79.44 Quite High
Myocardial Infarction 105 76.96 Quite High
Hypertrophy 2 75.36 Quite High
Hyperphagia 1 70.08 Quite High
Metabolic Syndrome 2 69.08 Quite High
Cardiovascular Disorder Under Development 1 60.88 Quite High
Cardiovascular Disease 1 50.48 Quite High
Overweight 1 40.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of MC3R led to reduced myocardial cytokine production and myeloperoxidase activity, and these effects were prevented by the mixed MC3/4R antagonist SHU9119, but not by the selective MC4R antagonist HS204 (Getting et al. 2004).
MC3 Binding (mixed) of in MC3 associated with antagonist and cytokine
1) Confidence 0.36 Published 2010 Journal The Journal of Endocrinology Section Body Doc Link PMC2887273 Disease Relevance 0.88 Pain Relevance 0.18
o during stimulation (compared to [9],[13] whereas mc3 and mc5 associated with H3 and H5 (NBC only and NBC+NKCC1, respectively) predict an increase in [Cl?]
mc3 Binding (associated) of
2) Confidence 0.04 Published 2009 Journal PLoS Computational Biology Section Body Doc Link PMC2613522 Disease Relevance 0 Pain Relevance 0
For the most part, differences in how laboratory animals and humans metabolize environmental agents, or in the interactions of these agents with molecular targets (e.g., DNA, enzymes, or nuclear receptors), are quantitative in nature [27].
quantitative Binding (interactions) of
3) Confidence 0.02 Published 2009 Journal Philos Ethics Humanit Med Section Body Doc Link PMC2642860 Disease Relevance 0.09 Pain Relevance 0

General Comments

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