INT257545

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Context Info
Confidence 0.11
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 8
Disease Relevance 6.60
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Mention Frequency
neurons 1
dta (Drosophila melanogaster)
Pain Term Frequency Confidence Heat
imagery 2 96.16 Very High Very High Very High
Enkephalin 3 89.80 High High
substance P 3 89.20 High High
Neuropeptide 1 83.52 Quite High
Substantia nigra 1 75.32 Quite High
projection neuron 2 70.80 Quite High
amygdala 11 56.52 Quite High
ketamine 6 51.36 Quite High
Nucleus accumbens 8 50.40 Quite High
anesthesia 7 6.56 Low Low
Disease Term Frequency Confidence Heat
Cancer 429 99.84 Very High Very High Very High
Pancreatic Cancer 192 99.48 Very High Very High Very High
Pressure And Volume Under Development 28 99.46 Very High Very High Very High
Death 13 98.36 Very High Very High Very High
Diphtheria 32 98.20 Very High Very High Very High
Disease 25 87.04 High High
Toxicity 10 76.92 Quite High
Metastasis 103 71.68 Quite High
Starvation 12 68.72 Quite High
Hypoxia 24 67.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Along with the NeuN-immunohistochemistry, our results suggest that induction of CrePR-mediated DTA expression by RU-486 injection successfully ablated almost completely the medium spiny neurons that comprise approximately 90% of the NeuN-positive striatal neurons within 13 days.
Gene_expression (expression) of DTA in neurons
1) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2613534 Disease Relevance 0.06 Pain Relevance 0.45
The rapid reduction of cells in the ascites fluid might indicate that DTA was expressed from the DTA-H19 vector and caused cell death.
Gene_expression (expressed) of DTA associated with pressure and volume under development and death
2) Confidence 0.04 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2918631 Disease Relevance 1.16 Pain Relevance 0.05
Therefore, inhibition of the growth of DTA-H19 treated tumors in the hamster results from the action of the DTA produced (Figure 6(a)).
Gene_expression (produced) of DTA associated with cancer
3) Confidence 0.04 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2967839 Disease Relevance 1.18 Pain Relevance 0
Therefore, the observed effect is more likely due to the cytotoxic effect of the DTA-H19 plasmid expression and not the result of competition between the two plasmids for the entry into the cell.
Gene_expression (expression) of DTA
4) Confidence 0.04 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2967839 Disease Relevance 0.51 Pain Relevance 0
The activity of the H19 promoter was demonstrated in the human and hamster pancreatic tumor cells tested, leading to DTA expression (Figures 2 and 3).
Gene_expression (expression) of DTA associated with pancreatic cancer
5) Confidence 0.04 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2967839 Disease Relevance 1.17 Pain Relevance 0
The ex vivo tumor volume average of the DTA-H19 treated group was almost half that of the control group (P??
Gene_expression (average) of DTA associated with cancer
6) Confidence 0.03 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2967839 Disease Relevance 1.29 Pain Relevance 0
g plasmid (DTA-H19 for treated group and Luc-H19 for control group) mixed with the nonviral transfectant polyethylenimine (Polyplus) (N/P = 6) diluted in 50??
Gene_expression (mixed) of DTA
7) Confidence 0.03 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2967839 Disease Relevance 0.50 Pain Relevance 0.03
The effect of the DTA-H19 plasmid cotransfected into cells with a second plasmid which encodes the luciferase gene under the control of the SV40 regulatory sequence caused inhibition of the luciferase activity at a dose-response manner in all the studied cell lines (Figure 3).
Gene_expression (cotransfected) of DTA
8) Confidence 0.03 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2967839 Disease Relevance 0.73 Pain Relevance 0

General Comments

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