INT257557

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.30
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.38
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (MAP3K11) cell death (MAP3K11) cytoskeleton (MAP3K11)
cytoplasm (MAP3K11)
Anatomy Link Frequency
pole 2
MAP3K11 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 2 79.48 Quite High
Inflammation 14 68.72 Quite High
Inflammatory response 3 66.40 Quite High
Somatostatin 4 8.84 Low Low
vincristine 18 5.00 Very Low Very Low Very Low
tolerance 6 5.00 Very Low Very Low Very Low
Antinociceptive 6 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
Analgesic 3 5.00 Very Low Very Low Very Low
agonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 32 98.88 Very High Very High Very High
Death 27 90.72 High High
Necrosis 10 70.32 Quite High
INFLAMMATION 17 68.72 Quite High
Injury 3 63.60 Quite High
Cancer 110 39.56 Quite Low
Shock 7 15.92 Low Low
Aging 60 11.84 Low Low
Stress 11 5.00 Very Low Very Low Very Low
Skin Cancer 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The latter data indicates that Petiveria alliacea F4 fraction might inhibit MLK3.
Spec (might) Negative_regulation (inhibit) of MLK3
1) Confidence 0.30 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2613870 Disease Relevance 0.87 Pain Relevance 0.03
Mixed-lineage kinase 3 (MLK-3, a kinase of the family controlling MAP kinases activity) inhibition, can cause mitotic arrest by a mechanism involving disruption of microtubule formation and spindle pole assembly [30].
Negative_regulation (inhibition) of MLK-3 in pole
2) Confidence 0.22 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2613870 Disease Relevance 0.61 Pain Relevance 0.03
Mixed-lineage kinase 3 (MLK-3, a kinase of the family controlling MAP kinases activity) inhibition, can cause mitotic arrest by a mechanism involving disruption of microtubule formation and spindle pole assembly [30].
Negative_regulation (inhibition) of Mixed-lineage kinase 3 in pole
3) Confidence 0.22 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2613870 Disease Relevance 0.61 Pain Relevance 0.03
Three important genes related to cell signaling showed significant downregulation in senescent cells: Mitogen-activated protein kinase 8 interacting protein 2, mitogen-activated protein kinase kinase kinase 11, and mitogen-activated protein kinase 2.
Negative_regulation (downregulation) of mitogen-activated protein kinase kinase kinase 11
4) Confidence 0.16 Published 2010 Journal BMC Biotechnol Section Body Doc Link PMC2828399 Disease Relevance 0.29 Pain Relevance 0.07

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox