INT25761

Context Info Confidence 0.45 First Reported 1989 Last Reported 1989 Negated 0 Speculated 2 Reported most in Abstract Documents 1 Total Number 2 Disease Relevance 0.15 Pain Relevance 0.65

extracellular space (Crh) extracellular region (Crh) response to stress (Crh) cytoplasm (Crh)

Anatomy Link Frequency AtT-20 2 anterior pituitary 2 Crh (Mus musculus)

Pain Link Frequency Relevance Heat Kinase C 4 100.00 Calcium channel 2 81.68 antagonist 6 80.40 sodium channel 2 69.20 tetrodotoxin 2 67.12 Action potential 2 60.24

Disease Link Frequency Relevance Heat Pituitary Cancer 2 75.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The mechanisms by which an activator of cyclic AMP-dependent protein kinase, corticotropin releasing factor (CRF) and the protein kinase C stimulant, phorbol myristate acetate (PMA) regulate the level of intracellular free calcium in the mouse anterior pituitary cell line AtT-20 were examined using the fluorescence probe Quin 2.

Regulation (regulate) of in AtT-20 Spec (examined) Positive_regulation (activator) of CRF in anterior pituitary associated with kinase c

1) Confidence 0.45 Published 1989 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2539467 Disease Relevance 0.07 Pain Relevance 0.32

The mechanisms by which an activator of cyclic AMP-dependent protein kinase, corticotropin releasing factor (CRF) and the protein kinase C stimulant, phorbol myristate acetate (PMA) regulate the level of intracellular free calcium in the mouse anterior pituitary cell line AtT-20 were examined using the fluorescence probe Quin 2.

Regulation (regulate) of in AtT-20 Spec (examined) Positive_regulation (activator) of corticotropin releasing factor in anterior pituitary associated with kinase c

2) Confidence 0.45 Published 1989 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2539467 Disease Relevance 0.07 Pain Relevance 0.32

General Comments

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