INT257639

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Context Info
Confidence 0.35
First Reported 2009
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 9
Disease Relevance 0.40
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Pard3) cytoskeleton (Pard3) cell cycle (Pard3)
cell division (Pard3) protein complex (Pard3) cytoplasm (Pard3)
Anatomy Link Frequency
tail 1
podocytes 1
Pard3 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 9 84.84 Quite High
anesthesia 9 5.00 Very Low Very Low Very Low
alcohol 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Focal Segmental Glomerulosclerosis 54 96.12 Very High Very High Very High
Nephrotic Syndrome 9 70.04 Quite High
Disease 45 68.04 Quite High
Renal Disease 27 41.92 Quite Low
Adhesions 9 27.72 Quite Low
Death 9 5.80 Low Low
Sprains And Strains 9 5.00 Very Low Very Low Very Low
Proteinuria 9 5.00 Very Low Very Low Very Low
Renal Failure 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We next addressed the possibility of direct interaction between PAR3 and nephrin in vitro.
PAR3 Binding (interaction) of
1) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2614475 Disease Relevance 0 Pain Relevance 0
Altogether, these data suggest that the aPKC–PAR complex interacts with the nephrin–podocin complex by direct binding between the PDZ domains of PAR3 and two cytoplasmic regions of nephrin, including the CT11 and ICD-A regions.


PAR3 Binding (binding) of
2) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2614475 Disease Relevance 0 Pain Relevance 0
Endogenous aPKC in 293T cells also interacted with GST–nephrinICD in a PAR3-dependent manner, confirming the formation of a ternary complex of PAR3, aPKC, and nephrin.
PAR3 Binding (complex) of
3) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2614475 Disease Relevance 0 Pain Relevance 0
The aPKC–PAR3 complex associates with the nephrin–podocin complex in podocytes through direct interaction between PAR3 and nephrin, and the kinase activity of aPKC is required for the appropriate distribution of nephrin and podocin in podocytes.
PAR3 Binding (interaction) of in podocytes
4) Confidence 0.27 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2614475 Disease Relevance 0.33 Pain Relevance 0.04
Although GST–nephrinICD2 can bind with the isolated first or third PDZ domains of PAR3, all three PDZ domains are required for efficient binding.
PAR3 Binding (bind) of
5) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2614475 Disease Relevance 0 Pain Relevance 0
Next, we used immunoprecipitation to examine whether endogenous PAR3 forms a protein complex with nephrin and podocin.
PAR3 Spec (whether) Binding (endogenous) of
6) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2614475 Disease Relevance 0 Pain Relevance 0
was reproducibly coprecipitated with PAR3 from both of the soluble fractions extracted from glomeruli (Figure 5B).
PAR3 Binding (coprecipitated) of
7) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2614475 Disease Relevance 0 Pain Relevance 0
aPKC–PAR3 complex associates with the nephrin–podocin complex
PAR3 Binding (complex) of
8) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2614475 Disease Relevance 0 Pain Relevance 0
In the regulation of actin cytoskeletons, the direct binding of the aPKC–PAR3 complex to the cytoplasmic tail of nephrin may compete with Nck and prevent the rearrangement of actin cytoskeletons in podocytes to maintain the integrity of the slit diaphragms [34], [35].
PAR3 Binding (binding) of in tail
9) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2614475 Disease Relevance 0.07 Pain Relevance 0

General Comments

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