INT257666

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Context Info
Confidence 0.05
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mgst1) endoplasmic reticulum (Mgst1) protein complex (Pard3)
cytoplasm (Pard3) lipid binding (Pard3) nucleus (Mgst1)
Mgst1 (Mus musculus)
Pard3 (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 2 5.00 Very Low Very Low Very Low
Kinase C 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Focal Segmental Glomerulosclerosis 12 5.00 Very Low Very Low Very Low
Disease 10 5.00 Very Low Very Low Very Low
Renal Disease 6 5.00 Very Low Very Low Very Low
Sprains And Strains 2 5.00 Very Low Very Low Very Low
Proteinuria 2 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low
Nephrotic Syndrome 2 5.00 Very Low Very Low Very Low
Adhesions 2 5.00 Very Low Very Low Very Low
Renal Failure 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
T7-tagged PAR3 mutants overexpressed in 293T cells specifically interacted with GST–nephrinICD, except for the mutants lacking all PDZ domains or mutated in the third PDZ domain [27], [28], indicating the third PDZ domain is required for the formation of the complex with nephrin (Figure 6B).
GST Binding (interacted) of PAR3
1) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2614475 Disease Relevance 0 Pain Relevance 0
Although GST–nephrinICD2 can bind with the isolated first or third PDZ domains of PAR3, all three PDZ domains are required for efficient binding.
GST Binding (bind) of PAR3
2) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2614475 Disease Relevance 0 Pain Relevance 0

General Comments

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