INT257683

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Context Info
Confidence 0.58
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 23
Disease Relevance 2.63
Pain Relevance 2.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gja3) plasma membrane (Gja3)
Anatomy Link Frequency
heart 16
myocytes 6
myocardium 2
Gja3 (Mus musculus)
Pain Link Frequency Relevance Heat
action potential duration 460 99.58 Very High Very High Very High
Action potential 230 99.48 Very High Very High Very High
Calcium channel 23 92.00 High High
ischemia 23 89.44 High High
sodium channel 46 86.12 High High
potassium channel 46 80.44 Quite High
anesthesia 23 5.00 Very Low Very Low Very Low
isoflurane 23 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 115 100.00 Very High Very High Very High
Heart Disease 69 98.80 Very High Very High Very High
Dilated Cardiomyopathy 23 92.00 High High
Infarction 23 89.92 High High
Cv Unclassified Under Development 46 89.44 High High
Heart Rate Under Development 23 87.36 High High
Myocardial Infarction 23 85.72 High High
Malignant Neoplastic Disease 23 84.48 Quite High
Sprains And Strains 23 83.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, in combination with the data presented in this study, it is reasonable to conclude that reduced Cx43 expression, as observed in the infarct border zone and in paced Cx43+/?
Negative_regulation (reduced) of Gene_expression (expression) of Cx43
1) Confidence 0.58 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Body Doc Link PMC2614590 Disease Relevance 0.17 Pain Relevance 0
Significant elevations in the 4-AP-insensitive current, Iss, have been described in right ventricular myocytes from mice with conditional loss of Cx43 expression in the heart (9).
Negative_regulation (loss) of Gene_expression (expression) of Cx43 in heart
2) Confidence 0.58 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Body Doc Link PMC2614590 Disease Relevance 0 Pain Relevance 0.06
We investigated the effect of reduced Cx43 expression on pacing-induced remodeling of repolarizing currents using Cx43+/?
Negative_regulation (reduced) of Gene_expression (expression) of Cx43
3) Confidence 0.58 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Body Doc Link PMC2614590 Disease Relevance 0.08 Pain Relevance 0.15
In another model of loss of Cx43 expression, the heart-specific conditional knockout of Cx43, we observed a reduction in APD with correspondingly increased outward potassium currents (9).
Negative_regulation (loss) of Gene_expression (expression) of Cx43 in heart associated with targeted disruption and action potential duration
4) Confidence 0.58 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Body Doc Link PMC2614590 Disease Relevance 0.20 Pain Relevance 0.12
To investigate how pacing in the setting of reduced Cx43 expression influences electrophysiological properties, we used whole-cell patch-clamp techniques to record action potentials in ventricular myocytes obtained from unpaced and paced wild-type and Cx43+/?
Negative_regulation (reduced) of Gene_expression (expression) of Cx43 in myocytes associated with action potential
5) Confidence 0.58 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Body Doc Link PMC2614590 Disease Relevance 0 Pain Relevance 0.23
In the clinical setting, dyssynchronous activation of diseased myocardium with reduced Cx43 expression may lead to electrophysiological changes, which underlie the worsened prognosis often associated with pacing in the failing heart.
Negative_regulation (reduced) of Gene_expression (expression) of Cx43 in heart
6) Confidence 0.58 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Body Doc Link PMC2614590 Disease Relevance 0.06 Pain Relevance 0.17
Our data suggest that decreased expression of Cx43, which has been described in heart disease (20, 21, 24, 30), can influence the expression and/or function of active ion channels and, in combination with pacing, may lead to increased dispersion of repolarization properties.
Negative_regulation (decreased) of Gene_expression (expression) of Cx43 in heart associated with heart disease
7) Confidence 0.58 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Body Doc Link PMC2614590 Disease Relevance 0.25 Pain Relevance 0.04
Experimental models have demonstrated the relationship between decreased cardiac Cx43 expression and increased susceptibility to ventricular arrhythmias.
Negative_regulation (decreased) of Gene_expression (expression) of Cx43
8) Confidence 0.58 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Body Doc Link PMC2614590 Disease Relevance 0.63 Pain Relevance 0.04
Taken together, these data suggest that short-term pacing in the setting of reduced Cx43 expression, but not wild-type levels of Cx43, results in the prolongation of refractoriness without significantly affecting overall ventricular function.


Negative_regulation (reduced) of Gene_expression (expression) of Cx43
9) Confidence 0.58 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Body Doc Link PMC2614590 Disease Relevance 0 Pain Relevance 0.11
Thus, although short-term pacing in the wild-type murine heart is not associated with measurable electrophysiological effects, pacing in the setting of reduced baseline Cx43 expression results in significant prolongation of refractoriness and altered repolarization.
Negative_regulation (reduced) of Gene_expression (expression) of Cx43 in heart
10) Confidence 0.43 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Body Doc Link PMC2614590 Disease Relevance 0.15 Pain Relevance 0.14
Our results suggest that the imposition of pacing in such a clinical scenario could lead to the remodeling of repolarization currents in regions with reduced Cx43 expression, thus greatly enhancing dispersion of refractoriness around hibernating or ischemic zones and potentially creating a substrate for reentry.


Negative_regulation (reduced) of Gene_expression (expression) of Cx43
11) Confidence 0.43 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Body Doc Link PMC2614590 Disease Relevance 0 Pain Relevance 0.16
To investigate the prolongation of refractoriness associated with pacing in the setting of reduced Cx43 expression, we studied action potentials and potassium currents from myocytes isolated from paced and unpaced Cx43 mutant and wild-type hearts.
Negative_regulation (reduced) of Gene_expression (expression) of Cx43 in hearts associated with action potential
12) Confidence 0.43 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Body Doc Link PMC2614590 Disease Relevance 0 Pain Relevance 0.13
In this paper, we describe an interaction between reduced basal levels of Cx43 and pacing that influences ventricular electrophysiology.
Negative_regulation (reduced) of Gene_expression (levels) of Cx43
13) Confidence 0.43 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Body Doc Link PMC2614590 Disease Relevance 0 Pain Relevance 0.11
In conclusion, the present findings suggest that myocardial tissue with reduced baseline expression of Cx43 responds quite differently to pacing than does myocardium with wild-type levels of Cx43.
Negative_regulation (reduced) of Gene_expression (expression) of Cx43 in myocardium
14) Confidence 0.43 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Body Doc Link PMC2614590 Disease Relevance 0.05 Pain Relevance 0.24
In the setting of decreased Cx43 expression, short-term pacing results in significant prolongation of refractoriness, as well as changes in APD and Iss.
Negative_regulation (decreased) of Gene_expression (expression) of Cx43 associated with action potential duration
15) Confidence 0.43 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Body Doc Link PMC2614590 Disease Relevance 0 Pain Relevance 0.23
In another model of loss of Cx43 expression, the heart-specific conditional knockout of Cx43, we observed a reduction in APD with correspondingly increased outward potassium currents (9).
Negative_regulation (loss) of Gene_expression (expression) of Cx43 in heart associated with targeted disruption and action potential duration
16) Confidence 0.42 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Body Doc Link PMC2614590 Disease Relevance 0.20 Pain Relevance 0.12
myocytes and lengthens to wild-type levels in the paced Cx43+/?
Negative_regulation (paced) of Gene_expression (/) of Cx43 in myocytes
17) Confidence 0.37 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Body Doc Link PMC2614590 Disease Relevance 0.16 Pain Relevance 0.15
Similarly, we found that Iss was significantly increased in unpaced Cx43+/?
Negative_regulation (unpaced) of Gene_expression (/) of Cx43
18) Confidence 0.37 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Body Doc Link PMC2614590 Disease Relevance 0 Pain Relevance 0.06
Thus, in combination with the data presented in this study, it is reasonable to conclude that reduced Cx43 expression, as observed in the infarct border zone and in paced Cx43+/?
Negative_regulation (observed) of Gene_expression (/) of Cx43
19) Confidence 0.37 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Body Doc Link PMC2614590 Disease Relevance 0.22 Pain Relevance 0
hearts, pacing resulted in a significant prolongation of ventricular effective refractory period and APD and significant diminution of Iss compared with unpaced Cx43+/?
Negative_regulation (unpaced) of Gene_expression (/) of Cx43 in hearts
20) Confidence 0.37 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Abstract Doc Link PMC2614590 Disease Relevance 0.07 Pain Relevance 0.04

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